| Gene Symbol |
CTDP1
|
| Entrez Gene |
9150
|
| Alt Symbol |
CCFDN, FCP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
|
| Other Description |
CTD of POLR2A, phosphatase of, subunit 1|RNA polymerase II subunit A C-terminal domain phosphatase|TFIIF-associating CTD phosphatase 1|serine phosphatase FCP1a|transcription factor IIF-associating CTD phosphatase 1
|
| Swissprots |
Q96BZ1 Q7Z644 Q9Y5B0 A8MY97 Q9Y6F5
|
| Accessions |
EAW66628 EAW66629 EAW66630 EAW66631 EAW66632 Q9Y5B0 AA282312 AF081287 AAC64549 AF154115 AAD42088 AK123180 BC015010 AAH15010 BC032515 BC047999 BC052576 AAH52576 BC063447 AAH63447 BM512113 BX103692 CF593225 DB451780 DB517021 DR001939 XM_005266782 XP_005266839 XM_011526261 XP_011524563 NM_001202504 NP_001189433 NM_004715 NP_004706 NM_048368 NP_430255
|
| Function |
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:22692537}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22692537}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:22692537}. Midbody {ECO:0000269|PubMed:22692537}. Note=Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:9765293}.
|