CTDP1

Gene Symbol	CTDP1
Entrez Gene	9150
Alt Symbol	CCFDN, FCP1
Species	Human
Gene Type	protein-coding
Description	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Other Description	CTD of POLR2A, phosphatase of, subunit 1|RNA polymerase II subunit A C-terminal domain phosphatase|TFIIF-associating CTD phosphatase 1|serine phosphatase FCP1a|transcription factor IIF-associating CTD phosphatase 1
Swissprots	Q96BZ1 Q7Z644 Q9Y5B0 A8MY97 Q9Y6F5
Accessions	EAW66628 EAW66629 EAW66630 EAW66631 EAW66632 Q9Y5B0 AA282312 AF081287 AAC64549 AF154115 AAD42088 AK123180 BC015010 AAH15010 BC032515 BC047999 BC052576 AAH52576 BC063447 AAH63447 BM512113 BX103692 CF593225 DB451780 DB517021 DR001939 XM_005266782 XP_005266839 XM_011526261 XP_011524563 NM_001202504 NP_001189433 NM_004715 NP_004706 NM_048368 NP_430255
Function	Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22692537}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22692537}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:22692537}. Midbody {ECO:0000269|PubMed:22692537}. Note=Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:9765293}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FCP1 peptide - ab23088 from Abcam Category Peptide Species Human

Human FCP1 protein fragment - ab160361 from Abcam Category Protein Source Wheat germ Species Human

CTDP1 / FCP1 Antibody Blocking Peptide - LS-E8345 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CTDP1 / FCP1 Antibody Blocking Peptide - LS-E23925 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FCP1 Partial Recombinant Protein - H00009150-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CTDP1-Antibody-N-term-Blocking-Peptide - BP6634a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FCP1 blocking peptide - GTX25270-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

CTDP1 - H00009150-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CTDP1 - H00009150-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Recombinant Human CTDP1, His-tagged - CTDP1-520H from Creative Biomart Category Protein Source E. coli.

Recombinant Human POLR2E - POLR2E-521H from Creative Biomart Category Protein Source E. coli.

Recombinant Human RNA polymerase II subunit A C-terminal domain phosphatase(CTDP - CSB-YP897499HU CSB-EP897499HU CSB-BP897499HU CSB-MP897499HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FCP1 Recombinant Protein Antigen - NBP1-84704PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CTDP1-Antibody-C-term-Blocking-Peptide - BP6634b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CTDP1 Peptide, Human - M34GP03789H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1), partial, Recombinant Protein - MBS1301179 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RNA polymerase II subunit A C-terminal domain phosphatase (FCP1), Recombinant Protein - MBS1470443 from MyBioSource Category Protein Prices $1,185.00, $1,185.00, $1,405.00, $1,405.00, $1,905.00, $1,905.00, $2,370.00, $2,370.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

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