CTDP1

Gene Symbol CTDP1
Entrez Gene 9150
Alt Symbol CCFDN, FCP1
Species Human
Gene Type protein-coding
Description CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Other Description CTD of POLR2A, phosphatase of, subunit 1|RNA polymerase II subunit A C-terminal domain phosphatase|TFIIF-associating CTD phosphatase 1|serine phosphatase FCP1a|transcription factor IIF-associating CTD phosphatase 1
Swissprots Q96BZ1 Q7Z644 Q9Y5B0 A8MY97 Q9Y6F5
Accessions EAW66628 EAW66629 EAW66630 EAW66631 EAW66632 Q9Y5B0 AA282312 AF081287 AAC64549 AF154115 AAD42088 AK123180 BC015010 AAH15010 BC032515 BC047999 BC052576 AAH52576 BC063447 AAH63447 BM512113 BX103692 CF593225 DB451780 DB517021 DR001939 XM_005266782 XP_005266839 XM_011526261 XP_011524563 NM_001202504 NP_001189433 NM_004715 NP_004706 NM_048368 NP_430255
Function Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}.
Subcellular Location Nucleus {ECO:0000269|PubMed:22692537}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22692537}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:22692537}. Midbody {ECO:0000269|PubMed:22692537}. Note=Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:9765293}.

FCP1 (H-300) - sc-32867 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

FCP1 (V-19) - sc-26623 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

FCP1a (C-16) - sc-26626 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FCP1a (C-16): sc-26626. Western blot analysis of FCP1a expression in Jurkat (A), NIH/3T3 (B) and K-562 (C) nuclear extracts.

FCP1b (F-20) - sc-26627 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FCP1b (F-20): sc-26627. Western blot analysis of FCP1 expression in non-transfected 293T: sc-117752 (A), human FCP1 transfected 293T: sc-116794 (B) and Jurkat (C) whole cell lysates.

Anti-FCP1 antibody - ab126107 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-FCP1 antibody (ab126107) at 1/1000 dilution + A549 cell lysate at 30 µg

Anti-FCP1 antibody - ab137683 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FCP1 antibody (ab137683) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : H1299 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-FCP1 antibody - ab88479 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-FCP1 antibody (ab88479) at 5 µg/ml + tagged, recombinant fragment of human FCP1 (the immunogen) at 0.2 µg

Anti-FCP1 antibody - ab133916 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FCP1 antibody (ab133916) at 1 µg/ml + Human fetal kidney lysate at 10 µg

Anti-FCP1 antibody - ab54534 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FCP1 antibody - ab5270 from Abcam

Prices $235.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FCP1 antibody - N-terminal - ab135588 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FCP1 antibody - N-terminal (ab135588) at 1/50 dilution + 293 cell lysate at 35 µg

Anti-CTDP1 / FCP1 Antibody - LS-C47098 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTDP1 / FCP1 Antibody (C-Terminus) - LS-C39780 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CTDP1 / FCP1 Antibody (N-Terminus, APC) - LS-C218860 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTDP1 / FCP1 Antibody (N-Terminus, Biotin) - LS-C218861 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTDP1 / FCP1 Antibody (N-Terminus, AP) - LS-C218862 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTDP1 / FCP1 Antibody (N-Terminus, FITC) - LS-C218863 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTDP1 / FCP1 Antibody (N-Terminus, Azide-free, HRP) - LS-C218864 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTDP1 / FCP1 Antibody (N-Terminus, PE) - LS-C218865 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTDP1 / FCP1 Antibody (aa521-570) - LS-C152061 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CTDP1 / FCP1 antibody Western Blot of Fetal kidney.

Anti-CTDP1 / FCP1 Antibody (phospho-Ser5, clone 8A7) - LS-C82294 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 8A7
Immunocytochemistry/ Immunofluorescence - RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody [8A7] in Human HeLa cells

Anti-CTDP1 / FCP1 Antibody (aa500-550) - LS-C287991 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTDP1 / FCP1 Antibody (aa911-961) - LS-C287993 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTDP1 / FCP1 Antibody (N-Terminus) - LS-C155400 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: A549 7.5% SDS PAGE CTDP1 / FCP1 antibody diluted at 1:1000

Anti-CTDP1 / FCP1 Antibody (N-Terminus) - LS-C327140 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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