CTDP1
| Gene Symbol | CTDP1 |
|---|---|
| Entrez Gene | 9150 |
| Alt Symbol | CCFDN, FCP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 |
| Other Description | CTD of POLR2A, phosphatase of, subunit 1|RNA polymerase II subunit A C-terminal domain phosphatase|TFIIF-associating CTD phosphatase 1|serine phosphatase FCP1a|transcription factor IIF-associating CTD phosphatase 1 |
| Swissprots | Q96BZ1 Q7Z644 Q9Y5B0 A8MY97 Q9Y6F5 |
| Accessions | EAW66628 EAW66629 EAW66630 EAW66631 EAW66632 Q9Y5B0 AA282312 AF081287 AAC64549 AF154115 AAD42088 AK123180 BC015010 AAH15010 BC032515 BC047999 BC052576 AAH52576 BC063447 AAH63447 BM512113 BX103692 CF593225 DB451780 DB517021 DR001939 XM_005266782 XP_005266839 XM_011526261 XP_011524563 NM_001202504 NP_001189433 NM_004715 NP_004706 NM_048368 NP_430255 |
| Function | Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:22692537}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22692537}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:22692537}. Midbody {ECO:0000269|PubMed:22692537}. Note=Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:9765293}. |
FCP1 CRISPR/Cas9 KO Plasmid (h) - sc-404732 from Santa Cruz Biotechnology
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FCP1 HDR Plasmid (h) - sc-404732-HDR from Santa Cruz Biotechnology
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FCP1 Double Nickase Plasmid (h) - sc-404732-NIC from Santa Cruz Biotechnology
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FCP1 Double Nickase Plasmid (h2) - sc-404732-NIC-2 from Santa Cruz Biotechnology
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FCP1 CRISPR Activation Plasmid (h) - sc-404732-ACT from Santa Cruz Biotechnology
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FCP1 CRISPR Activation Plasmid (h2) - sc-404732-ACT-2 from Santa Cruz Biotechnology
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FCP1 Lentiviral Activation Particles (h) - sc-404732-LAC from Santa Cruz Biotechnology
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FCP1 Lentiviral Activation Particles (h2) - sc-404732-LAC-2 from Santa Cruz Biotechnology
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FCP1a siRNA (h) - sc-39017 from Santa Cruz Biotechnology
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FCP1a shRNA Plasmid (h) - sc-39017-SH from Santa Cruz Biotechnology
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FCP1a shRNA (h) Lentiviral Particles - sc-39017-V from Santa Cruz Biotechnology
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FCP1 siRNA (h) - sc-44888 from Santa Cruz Biotechnology
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FCP1 shRNA Plasmid (h) - sc-44888-SH from Santa Cruz Biotechnology
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FCP1 shRNA (h) Lentiviral Particles - sc-44888-V from Santa Cruz Biotechnology
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FCP1 RNAi - H00009150-R01 from Novus Biologicals
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FCP1 RNAi - H00009150-R02 from Novus Biologicals
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MISSION® Human Phosphatase - SIHP0069 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0932 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0067 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0068 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6724 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6724 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06721 from Sigma-Aldrich
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CTDP1 siRNA (Human) - CRH6056 from Cohesion Biosciences
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CTDP1 - MBS8238213 from MyBioSource
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