| Gene Symbol |
NFE2L2
|
| Entrez Gene |
4780
|
| Alt Symbol |
NRF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor, erythroid 2-like 2
|
| Other Description |
HEBP1|NF-E2-related factor 2|NFE2-related factor 2|nuclear factor (erythroid-derived 2)-like 2|nuclear factor erythroid 2-related factor 2|nuclear factor erythroid-derived 2-like 2|nuclear factor, erythroid derived 2, like 2
|
| Swissprots |
Q59HH2 B4E338 E9PGJ7 B2RBU2 Q96F71 Q53RW6 Q16236
|
| Accessions |
AAY14710 EAX11061 EAX11062 Q16236 AB208786 BAD92023 AF323119 AAK01657 AK297838 BAG60172 AK304555 BAG65350 AK310656 AK310841 AK311395 AK311688 AK314816 BAG37339 AK316148 BAH14519 AW471118 BC011558 AAH11558 BX649047 BX649071 CV575212 DA436387 DC314553 EU446639 ABZ92168 EU831991 ACE87432 EU832084 ACE86746 EU832824 ACE87835 GQ129228 ACT64362 HM446346 ADK56055 S74017 AAB32188 NM_001145412 NP_001138884 NM_001145413 NP_001138885 NM_006164 NP_006155
|
| Function |
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. {ECO:0000269|PubMed:11035812}.
|
| Subcellular Location |
Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
|
| Tissue Specificity |
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|