| Gene Symbol |
ECSCR
|
| Entrez Gene |
641700
|
| Alt Symbol |
ARIA, ECSM2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
endothelial cell surface expressed chemotaxis and apoptosis regulator
|
| Other Description |
apoptosis regulator through modulating IAP expression|endothelial cell-specific chemotaxis regulator|endothelial cell-specific molecule 2
|
| Swissprots |
B4E3H7 Q19T08 C3RSF2
|
| Accessions |
Q19T08 AI699314 BC146912 AAI46913 BC146913 AAI46914 BF526332 BI834795 DQ462572 ABE73209 EU025066 ABW05062 NM_001077693 NP_001071161 NM_001293739 NP_001280668 NR_121659
|
| Function |
Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. {ECO:0000269|PubMed:18556573, ECO:0000269|PubMed:19416853}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
|
| Tissue Specificity |
Highest expression in endothelial cells. Also detected in vascular smooth muscle, macrophages, lymphocytes, and mast cells. {ECO:0000269|PubMed:18556573, ECO:0000269|PubMed:19416853}.
|