Gene Symbol | ECSCR |
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Entrez Gene | 641700 |
Alt Symbol | ARIA, ECSM2 |
Species | Human |
Gene Type | protein-coding |
Description | endothelial cell surface expressed chemotaxis and apoptosis regulator |
Other Description | apoptosis regulator through modulating IAP expression|endothelial cell-specific chemotaxis regulator|endothelial cell-specific molecule 2 |
Swissprots | B4E3H7 Q19T08 C3RSF2 |
Accessions | Q19T08 AI699314 BC146912 AAI46913 BC146913 AAI46914 BF526332 BI834795 DQ462572 ABE73209 EU025066 ABW05062 NM_001077693 NP_001071161 NM_001293739 NP_001280668 NR_121659 |
Function | Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. {ECO:0000269|PubMed:18556573, ECO:0000269|PubMed:19416853}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cytoplasm. |
Tissue Specificity | Highest expression in endothelial cells. Also detected in vascular smooth muscle, macrophages, lymphocytes, and mast cells. {ECO:0000269|PubMed:18556573, ECO:0000269|PubMed:19416853}. |
ECSCR Antibody Blocking Peptide - LS-E5502 from LifeSpan Bioscience
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ECSCR-Antibody-C-term-Blocking-Peptide - BP18022b from Abgent, a WuXi AppTec company
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Recombinant Human Endothelial cell-specific chemotaxis regulator(ECSCR) - CSB-YP007385HU CSB-EP007385HU CSB-BP007385HU CSB-MP007385HU from Cusabio
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ECSM2, Peptide - MBS428234 from MyBioSource
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ECSCR Peptide, Human - M34GP04701H from Creative Peptides
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Endothelial cell-specific chemotaxis regulator (ECSCR), Recombinant Protein - MBS1369916 from MyBioSource
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