| Gene Symbol |
TLN1
|
| Entrez Gene |
7094
|
| Alt Symbol |
ILWEQ, TLN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
talin 1
|
| Other Description |
talin-1
|
| Swissprots |
A6NMY0 Q9UPX3 Q9UHH8 Q9NZQ2 Q86YD0 Q9Y490
|
| Accessions |
AAF27330 EAW58352 EAW58353 Q9Y490 AB028950 BAA82979 AF078828 AAD13152 AF113217 AAG39288 AF177198 AAF23322 BC020881 BC042923 AAH42923 Z50170 NM_006289 NP_006280
|
| Function |
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity). {ECO:0000250}.
|
| Top Pathways |
Focal adhesion, HTLV-I infection, Rap1 signaling pathway
|