| Gene Symbol |
NAT8L
|
| Entrez Gene |
339983
|
| Alt Symbol |
CML3, NACED, NAT8-LIKE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-acetyltransferase 8-like (GCN5-related, putative)
|
| Other Description |
N-acetylaspartate synthetase|NAA synthetase|camello-like protein 3
|
| Swissprots |
Q8N9F0
|
| Accessions |
EAW82541 Q8N9F0 AK094797 BAC04426 BC010045 BC093906 AAH93906 BC093908 AAH93908 BC103748 AAI03749 NM_178557 NP_848652
|
| Function |
Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. {ECO:0000269|PubMed:19524112}.
|
| Subcellular Location |
Cytoplasm. Membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Mitochondrion membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment.
|
| Tissue Specificity |
Expressed in brain. {ECO:0000269|PubMed:19807691}.
|
| Top Pathways |
Alanine, aspartate and glutamate metabolism
|
![Western Blot: NAT8L Overexpression Lysate (Adult Normal) [NBL1-13493] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NAT8L.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/8705_NAT8L%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-13493-img0002.jpg)