ATG12

Gene Symbol	ATG12
Entrez Gene	9140
Alt Symbol	APG12, APG12L, FBR93, HAPG12
Species	Human
Gene Type	protein-coding
Description	autophagy related 12
Other Description	ATG12 autophagy related 12 homolog|Apg12 (autophagy, yeast) homolog|ubiquitin-like protein ATG12
Swissprots	O94817 Q6PJV2
Accessions	EAW48954 EAW48955 EAW48956 O94817 AB002440 AB002449 AB017507 BAA36493 AK098251 AK313320 BAG36125 AL161968 BC011033 AAH11033 BC012266 AAH12266 BM697565 BP335591 BX327373 CB995198 CN400030 CR978239 DA005347 DB048378 DB530852 EU554057 ACD74941 NR_073604 NM_001277783 NP_001264712 NM_004707 NP_004698 NR_033362 NR_033363 NR_073603
Function	Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. {ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:17999726, ECO:0000269|PubMed:19074260, ECO:0000269|PubMed:19164948, ECO:0000269|PubMed:19666601, ECO:0000269|PubMed:23202584}.
Subcellular Location	Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000269|PubMed:22342342}; Peripheral membrane protein {ECO:0000269|PubMed:22342342}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:9852036}.
Top Pathways	RIG-I-like receptor signaling pathway, Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human APG12 / ATG12 ELISA Kit (Sandwich ELISA) - LS-F10894 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Ubiquitin-like protein ATG12 (ATG12), Human, ELISA Kit - CSB-EL002283HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Ubiquitin-like protein ATG12, ATG12, Human, ELISA Kit - E2478h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

ATG12 autophagy related 12 homolog (S. cerevisiae) , ELISA Kit - MBS944212 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human ATG12 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 25 pg/ml -1600 pg/ml.

ELISA Kit for Autophagy Related Protein 12 (ATG12) - SEL224Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Autophagy Related Protein 12 (ATG12) - SEL224Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 13.1pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA’s were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

Human Ubiquitin-like protein ATG12(ATG12) ELISA kit - CSB-EL002283HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

ELISA Kit for Autophagy Related Protein 12 (ATG12) - SEL224Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat APG12 / ATG12 ELISA Kit (Custom ELISA) - LS-F19760 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse APG12 / ATG12 ELISA Kit (Custom ELISA) - LS-F19761 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Bovine APG12 / ATG12 ELISA Kit (Custom ELISA) - LS-F19759 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human APG12 / ATG12 ELISA Kit (Sandwich ELISA) - LS-F25582 from LifeSpan Bioscience Category ELISA Kit Prices $850.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.156-10 ng/ml

Mouse APG12 / ATG12 ELISA Kit (Sandwich ELISA) - LS-F25583 from LifeSpan Bioscience Category ELISA Kit Prices $880.00 Sizes 1 plate Sensitivity 13.1 pg/ml Range 0.156-10 ng/ml

ATG12 - EKH4448 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

ATG12 ELISA Kit (Human) : 96 Wells (OKEH01650) - OKEH01650 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.078 ng/mL Range 0.156 - 10 ng/mL

Human ATG12 ELISA Kit - E003934 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human ATG12 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the me

Human Ubiquitin-like protein ATG12 ELISA Kit - EK4519 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.43ng/mL Range 0.78-50 ng/mL

anti-ATG12 antibody - ARG56217 from Arigo Biolaboratories Category ELISA Kit

anti-ATG12 antibody - ARG54815 from Arigo Biolaboratories Category ELISA Kit

Ubiquitin-like protein ATG12, ELISA Kit - MBS9428345 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.078ng/mL Range 0.156-10 ng/mL

Ubiquitin-like protein ATG12, ELISA Kit - MBS2881422 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

Ubiquitin-like protein ATG12, ELISA Kit - MBS764834 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Human APG12 / ATG12 ELISA Kit (Sandwich ELISA) - LS-F35981 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.094 Range 0.156-10 ng/ml

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