ATG12

Gene Symbol	ATG12
Entrez Gene	9140
Alt Symbol	APG12, APG12L, FBR93, HAPG12
Species	Human
Gene Type	protein-coding
Description	autophagy related 12
Other Description	ATG12 autophagy related 12 homolog|Apg12 (autophagy, yeast) homolog|ubiquitin-like protein ATG12
Swissprots	O94817 Q6PJV2
Accessions	EAW48954 EAW48955 EAW48956 O94817 AB002440 AB002449 AB017507 BAA36493 AK098251 AK313320 BAG36125 AL161968 BC011033 AAH11033 BC012266 AAH12266 BM697565 BP335591 BX327373 CB995198 CN400030 CR978239 DA005347 DB048378 DB530852 EU554057 ACD74941 NR_073604 NM_001277783 NP_001264712 NM_004707 NP_004698 NR_033362 NR_033363 NR_073603
Function	Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. {ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:17999726, ECO:0000269|PubMed:19074260, ECO:0000269|PubMed:19164948, ECO:0000269|PubMed:19666601, ECO:0000269|PubMed:23202584}.
Subcellular Location	Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000269|PubMed:22342342}; Peripheral membrane protein {ECO:0000269|PubMed:22342342}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:9852036}.
Top Pathways	RIG-I-like receptor signaling pathway, Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-ATG12-cDNA-Clone - DC03063 from Abgent, a WuXi AppTec company Prices $252.45 Sizes 10 µg Species Human Accession BC012266

ATG12 - MBS1272345 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC011033

ATG12 - MBS1267491 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC012266

Human ATG12/Apg12 Gene ORF cDNA clone in cloning vector - HG11111-M from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid - HG11111-UT from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11111-M-F from Sino Biological Species Human

Human ATG12 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11111-M-N from Sino Biological Species Human Accession NM_004707.2

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11111-ACG from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11111-NY from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, N-His tag - HG11111-NH from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11111-NF from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, C-His tag - HG11111-CH from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11111-NM from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11111-CF from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11111-ANG from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11111-CM from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11111-ACR from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11111-ANR from Sino Biological Species Human

Human ATG12/Apg12 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11111-CY from Sino Biological Species Human

Human ATG12 ORF Clone (BC011033) - CDCS411921 from Creative biogene Species Human Accession O94817

Human ATG12 ORF Clone (BC012266) - CDCS411922 from Creative biogene Species Human Accession O94817

Search more