ATG12

Gene Symbol	ATG12
Entrez Gene	9140
Alt Symbol	APG12, APG12L, FBR93, HAPG12
Species	Human
Gene Type	protein-coding
Description	autophagy related 12
Other Description	ATG12 autophagy related 12 homolog|Apg12 (autophagy, yeast) homolog|ubiquitin-like protein ATG12
Swissprots	O94817 Q6PJV2
Accessions	EAW48954 EAW48955 EAW48956 O94817 AB002440 AB002449 AB017507 BAA36493 AK098251 AK313320 BAG36125 AL161968 BC011033 AAH11033 BC012266 AAH12266 BM697565 BP335591 BX327373 CB995198 CN400030 CR978239 DA005347 DB048378 DB530852 EU554057 ACD74941 NR_073604 NM_001277783 NP_001264712 NM_004707 NP_004698 NR_033362 NR_033363 NR_073603
Function	Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. {ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:17999726, ECO:0000269|PubMed:19074260, ECO:0000269|PubMed:19164948, ECO:0000269|PubMed:19666601, ECO:0000269|PubMed:23202584}.
Subcellular Location	Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000269|PubMed:22342342}; Peripheral membrane protein {ECO:0000269|PubMed:22342342}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:9852036}.
Top Pathways	RIG-I-like receptor signaling pathway, Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Apg12 full length protein - ab160354 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Apg12 full length protein - ab160355 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

APG12 / ATG12 Antibody Blocking Peptide - LS-E1042 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APG12 / ATG12 Antibody Blocking Peptide - LS-E5641 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APG12 / ATG12 Antibody Blocking Peptide - LS-E19516 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APG12 / ATG12 Antibody Blocking Peptide - LS-E21596 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APG12 / ATG12 Antibody Blocking Peptide - LS-E30430 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

APG12 / ATG12 Antibody Blocking Peptide - LS-E30431 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human ATG12 Protein - H00009140-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ATG12 Protein - H00009140-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ATG12 Blocking Peptide - NBP1-76861PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

ATG12 Blocking Peptide - NBP1-76860PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

ATG12-Antibody-N-term-Blocking-Peptide - BP1151a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG12-Antibody-N-term-Blocking-peptide - BP1816a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG12 Recombinant Protein - GTX48095-PRO from GeneTex Category Protein Prices $299.00 Sizes 50 μg Source E. coli Species Human

ATG12 Blocking Peptide - 33R-4374 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Atg12 Blocking Peptide - 33R-9272 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ATG12 Blocking Peptide - 33R-10994 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

ATG12 / APG12 - H00009140-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ATG12 / APG12 - H00009140-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ATG12 / APG12 - H00009140-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

ATG12 / APG12 - H00009140-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ATG12 / APG12 - H00009140-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ATG12 Peptide - 4421P from ProSci Category Peptide Species Human

ATG12 Peptide - 4423P from ProSci Category Peptide Species Human

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