| Gene Symbol |
ATG12
|
| Entrez Gene |
9140
|
| Alt Symbol |
APG12, APG12L, FBR93, HAPG12
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
autophagy related 12
|
| Other Description |
ATG12 autophagy related 12 homolog|Apg12 (autophagy, yeast) homolog|ubiquitin-like protein ATG12
|
| Swissprots |
O94817 Q6PJV2
|
| Accessions |
EAW48954 EAW48955 EAW48956 O94817 AB002440 AB002449 AB017507 BAA36493 AK098251 AK313320 BAG36125 AL161968 BC011033 AAH11033 BC012266 AAH12266 BM697565 BP335591 BX327373 CB995198 CN400030 CR978239 DA005347 DB048378 DB530852 EU554057 ACD74941 NR_073604 NM_001277783 NP_001264712 NM_004707 NP_004698 NR_033362 NR_033363 NR_073603
|
| Function |
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. {ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:17999726, ECO:0000269|PubMed:19074260, ECO:0000269|PubMed:19164948, ECO:0000269|PubMed:19666601, ECO:0000269|PubMed:23202584}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000269|PubMed:22342342}; Peripheral membrane protein {ECO:0000269|PubMed:22342342}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:9852036}.
|
| Top Pathways |
RIG-I-like receptor signaling pathway, Regulation of autophagy
|
![Western Blot: ATG12 Overexpression Lysate (Adult Normal) [NBL1-07795] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ATG12.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3874_ATG12%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07795-img0002.jpg)