C14orf169

Gene Symbol C14orf169
Entrez Gene 79697
Alt Symbol MAPJD, NO66, ROX, URLC2, hsNO66
Species Human
Gene Type protein-coding
Description chromosome 14 open reading frame 169
Other Description 60S ribosomal protein L8 histidine hydroxylase|MYC-associated protein with JmjC domain|bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66|histone lysine demethylase NO66|lysine-specific demethylase NO66|nucleolar protein 66|ribosomal oxygenase NO66|up-regulated in lung cancer 2
Swissprots Q9H6W3 B4DT02
Accessions Q9H6W3 AB101204 BAQ19748 AK025455 BAB15138 AK299994 BAG61814 AY390535 AAR27292 BC011350 AAH11350 BC071954 AAH71954 BX390965 CN259773 DA509240 DA872764 HY178771 NM_024644 NP_078920
Function Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC- induced transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:14742713, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}.
Subcellular Location Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli.
Tissue Specificity Widely expressed. Overexpressed in lung carcinomas. {ECO:0000269|PubMed:14742713, ECO:0000269|PubMed:17308053}.

NO66 (E-8) - sc-390421 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NO66 (E-8): sc-390421. Western blot analysis of NO66 expression in Hep G2 whole cell lysate.

NO66 (H-236) - sc-292863 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NO66 (H-236): sc-292863. Western blot analysis of NO66 expression in non-transfected: sc-110760 (A) and human NO66 transfected: sc-111061 (B) 293 whole cell lysates.

NO66 (C-18) - sc-70296 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NO66 (C-18): sc-70296. Western blot analysis of NO66 expression in non-transfected: sc-117750 (A) and human NO66 transfected: sc-111061 (B) whole cell lysates.

NO66 (P-25) - sc-133835 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
NO66 (P-25): sc-133835. Western blot analysis of NO66 expression in Hep G2 whole cell lysate.

NO66 (3354C5a) - sc-81341 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NO66 (3354C5a): sc-81341. Western blot analysis of NO66 expression in non-transfected: sc-110760 (A) and human NO66 transfected: sc-111061 (B) 293 whole cell lysates.

Anti-C14orf169 / NO66 antibody - ab113975 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-C14orf169 / NO66 antibody (ab113975) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-C14orf169 / NO66 antibody - ab25941 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-C14orf169 / NO66 antibody (ab25941) at 1.25 µg/ml + HepG2 cell lysateSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-C14orf169 / NO66 antibody [3354C5a] - ab54278 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3354C5a
Staining of recombinant immunising protein using anti-C14orf169 / NO66 antibody [3354C5a] (ab54278).

Anti-C14orf169 / NO66 Antibody - LS-C79316 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-C14orf169 / NO66 Antibody (clone 3354C5a) - LS-C184499 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3354C5a

Anti-C14orf169 / NO66 Antibody (aa67-116) - LS-C31355 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-C14orf169 / NO66 Antibody (aa1-50) - LS-C289894 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-C14orf169 / NO66 Antibody (aa50-100) - LS-C289895 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-C14orf169 / NO66 Antibody (aa463-473) - LS-C61715 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.3 ug/ml) staining of A431 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-C14orf169 / NO66 Antibody (clone 3354C5a) - LS-C342540 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3354C5a
Western blot analysis of immunized recombinant protein, using anti-C14orf169 monoclonal antibody.

NO66 Antibody - NB100-93381 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: NO66 Antibody [NB100-93381] - Staining of A431 cell lysate.

NO66 Antibody - NBP2-15042 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NO66 Antibody [NBP2-15042] - Sample (30 ug of whole cell lysate) A: NT2D1 10% SDS PAGE, antibody diluted at 1:3000.

NO66 Antibody - H00079697-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-C14orf169 antibody produced in mouse - SAB1409815 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-C14orf169: <B>Cat. No. SAB1409815</B>: Antibody concentration: 10 μg/mL using HeLa cell.

C14ORF169 antibody - N-terminal region (ARP33580_T100) - ARP33580_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NO66 Antibody - middle region (ARP75773_P050) - ARP75773_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C14orf169--NO66-Antibody - AF1170a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF1170a (0.3 µg/ml) staining of A431 cell lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

C14orf169 / NO66 antibody, Internal - GTX88860 from GeneTex

Prices $299.00
Sizes 100 μg
Anti-C14orf169 / NO66 antibody, Internal used in Western blot. GTX88860

C14orf169 / NO66 antibody [C2C3], C-term - GTX119355 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-NO66 antibody [C2C3], C-term used in Western blot. GTX119355
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