| Gene Symbol |
C14orf169
|
| Entrez Gene |
79697
|
| Alt Symbol |
MAPJD, NO66, ROX, URLC2, hsNO66
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromosome 14 open reading frame 169
|
| Other Description |
60S ribosomal protein L8 histidine hydroxylase|MYC-associated protein with JmjC domain|bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66|histone lysine demethylase NO66|lysine-specific demethylase NO66|nucleolar protein 66|ribosomal oxygenase NO66|up-regulated in lung cancer 2
|
| Swissprots |
Q9H6W3 B4DT02
|
| Accessions |
Q9H6W3 AB101204 BAQ19748 AK025455 BAB15138 AK299994 BAG61814 AY390535 AAR27292 BC011350 AAH11350 BC071954 AAH71954 BX390965 CN259773 DA509240 DA872764 HY178771 NM_024644 NP_078920
|
| Function |
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC- induced transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:14742713, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}.
|
| Subcellular Location |
Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli.
|
| Tissue Specificity |
Widely expressed. Overexpressed in lung carcinomas. {ECO:0000269|PubMed:14742713, ECO:0000269|PubMed:17308053}.
|