C14orf169

Gene Symbol C14orf169
Entrez Gene 79697
Alt Symbol MAPJD, NO66, ROX, URLC2, hsNO66
Species Human
Gene Type protein-coding
Description chromosome 14 open reading frame 169
Other Description 60S ribosomal protein L8 histidine hydroxylase|MYC-associated protein with JmjC domain|bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66|histone lysine demethylase NO66|lysine-specific demethylase NO66|nucleolar protein 66|ribosomal oxygenase NO66|up-regulated in lung cancer 2
Swissprots Q9H6W3 B4DT02
Accessions Q9H6W3 AB101204 BAQ19748 AK025455 BAB15138 AK299994 BAG61814 AY390535 AAR27292 BC011350 AAH11350 BC071954 AAH71954 BX390965 CN259773 DA509240 DA872764 HY178771 NM_024644 NP_078920
Function Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC- induced transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:14742713, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}.
Subcellular Location Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli.
Tissue Specificity Widely expressed. Overexpressed in lung carcinomas. {ECO:0000269|PubMed:14742713, ECO:0000269|PubMed:17308053}.

NO66 CRISPR/Cas9 KO Plasmid (h) - sc-409536 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NO66 HDR Plasmid (h) - sc-409536-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NO66 Double Nickase Plasmid (h) - sc-409536-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NO66 Double Nickase Plasmid (h2) - sc-409536-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NO66 CRISPR Activation Plasmid (h) - sc-409536-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NO66 CRISPR Activation Plasmid (h2) - sc-409536-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NO66 Lentiviral Activation Particles (h) - sc-409536-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NO66 Lentiviral Activation Particles (h2) - sc-409536-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NO66 siRNA (h) - sc-75939 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NO66 shRNA Plasmid (h) - sc-75939-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NO66 shRNA (h) Lentiviral Particles - sc-75939-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN4334 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4334 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04175 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04175

NO66 siRNA (Human) - CRJ2495 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human C14orf169 (NM_024644.2) - SHH249406 from Creative biogene

Category siRNA
Species Reactivities Human

Human NO66 siRNA - orb272996 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Rat NO66 siRNA - orb300314 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol

NO66 shRNA Plasmid (Human) - CHJ2495 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

C14ORF169 miRNA 3'UTR clone - MiUTR1H-01107 from Creative biogene

Species Reactivities Human
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