C14orf169

Gene Symbol C14orf169
Entrez Gene 79697
Alt Symbol MAPJD, NO66, ROX, URLC2, hsNO66
Species Human
Gene Type protein-coding
Description chromosome 14 open reading frame 169
Other Description 60S ribosomal protein L8 histidine hydroxylase|MYC-associated protein with JmjC domain|bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66|histone lysine demethylase NO66|lysine-specific demethylase NO66|nucleolar protein 66|ribosomal oxygenase NO66|up-regulated in lung cancer 2
Swissprots Q9H6W3 B4DT02
Accessions Q9H6W3 AB101204 BAQ19748 AK025455 BAB15138 AK299994 BAG61814 AY390535 AAR27292 BC011350 AAH11350 BC071954 AAH71954 BX390965 CN259773 DA509240 DA872764 HY178771 NM_024644 NP_078920
Function Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC- induced transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:14742713, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}.
Subcellular Location Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli.
Tissue Specificity Widely expressed. Overexpressed in lung carcinomas. {ECO:0000269|PubMed:14742713, ECO:0000269|PubMed:17308053}.

Human C14orf169 / NO66 full length protein - ab164082 from Abcam

Category Protein
Prices $402.00
Sizes 2 µg
Source Wheat germ
Species Human
ab164082 on a 12.5% SDS-PAGE stained with Coomassie Blue.

C14orf169 / NO66 Antibody Blocking Peptide - LS-E11869 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

C14orf169 / NO66 Antibody Blocking Peptide - LS-E26266 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human NO66 Protein - H00079697-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

C14orf169 / NO66 blocking peptide - GTX88860-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Human, Mouse, Rat

C14ofr169 / NO66 Peptide - AC21-1098-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

NO66 - H00079697-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

NO66 Peptide - 46-636P from ProSci

Category Peptide
Species Human

C14orf169 fusion protein - Ag19281 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

C14orf169 fusion protein - ag18721 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human C14orf169, His-tagged - C14orf169-10391H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Lysine-specific demethylase NO66(NO66) - CSB-YP887992HU CSB-EP887992HU CSB-BP887992HU CSB-MP887992HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

C14orf169, Peptide - MBS659528 from MyBioSource

Category Peptide
Prices $340.00
Sizes 100 µg

C14orf169/NO66, Peptide - MBS426821 from MyBioSource

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human, Mouse, Rat

C14ORF169 Peptide, Human - M34GP01715H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

NO66 Recombinant Protein Antigen - NBP2-58770PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Lysine-specific demethylase NO66 (NO66), Recombinant Protein - MBS1317839 from MyBioSource

Category Protein
Prices $1,440.00, $1,440.00, $1,665.00, $1,665.00, $2,440.00, $2,440.00, $2,885.00, $2,885.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

C14orf169 Immunizing peptide - orb16916 from Biorbyt

Category Peptide
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