| Gene Symbol | CYP2J2 |
|---|---|
| Entrez Gene | 1573 |
| Alt Symbol | CPJ2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 2, subfamily J, polypeptide 2 |
| Other Description | CYPIIJ2|arachidonic acid epoxygenase|cytochrome P450 2J2|cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2|flavoprotein-linked monooxygenase|microsomal monooxygenase |
| Swissprots | P51589 B2RD33 Q8TF13 |
| Accessions | AAK63192 AAM44456 AAQ93356 EAX06611 EAX06612 EAX06613 EAX06614 P51589 AB080265 BAB85489 AF144566 AAD30164 AK055088 AK315387 BAG37780 BC032594 AAH32594 DQ890862 ABM81788 DQ894017 ABM84943 U37143 AAC50370 XR_246240 XR_946558 NM_000775 NP_000766 |
| Function | This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools. |
| Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Tissue Specificity | Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney. |
| Top Pathways | Ovarian steroidogenesis, Inflammatory mediator regulation of TRP channels, Arachidonic acid metabolism, Linoleic acid metabolism |