Gene Symbol | CYP2J2 |
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Entrez Gene | 1573 |
Alt Symbol | CPJ2 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 2, subfamily J, polypeptide 2 |
Other Description | CYPIIJ2|arachidonic acid epoxygenase|cytochrome P450 2J2|cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2|flavoprotein-linked monooxygenase|microsomal monooxygenase |
Swissprots | P51589 B2RD33 Q8TF13 |
Accessions | AAK63192 AAM44456 AAQ93356 EAX06611 EAX06612 EAX06613 EAX06614 P51589 AB080265 BAB85489 AF144566 AAD30164 AK055088 AK315387 BAG37780 BC032594 AAH32594 DQ890862 ABM81788 DQ894017 ABM84943 U37143 AAC50370 XR_246240 XR_946558 NM_000775 NP_000766 |
Function | This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Tissue Specificity | Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney. |
Top Pathways | Ovarian steroidogenesis, Inflammatory mediator regulation of TRP channels, Arachidonic acid metabolism, Linoleic acid metabolism |
CYP2J2 CRISPR/Cas9 KO Plasmid (h) - sc-402955 from Santa Cruz Biotechnology
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CYP2J2 HDR Plasmid (h) - sc-402955-HDR from Santa Cruz Biotechnology
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CYP2J2 Double Nickase Plasmid (h) - sc-402955-NIC from Santa Cruz Biotechnology
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CYP2J2 Double Nickase Plasmid (h2) - sc-402955-NIC-2 from Santa Cruz Biotechnology
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CYP2J2 CRISPR Activation Plasmid (h) - sc-402955-ACT from Santa Cruz Biotechnology
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CYP2J2 CRISPR Activation Plasmid (h2) - sc-402955-ACT-2 from Santa Cruz Biotechnology
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CYP2J2 Lentiviral Activation Particles (h) - sc-402955-LAC from Santa Cruz Biotechnology
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CYP2J2 Lentiviral Activation Particles (h2) - sc-402955-LAC-2 from Santa Cruz Biotechnology
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CYP2J2 siRNA (h) - sc-62184 from Santa Cruz Biotechnology
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CYP2J2 shRNA Plasmid (h) - sc-62184-SH from Santa Cruz Biotechnology
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CYP2J2 shRNA (h) Lentiviral Particles - sc-62184-V from Santa Cruz Biotechnology
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Cytochrome p450 2J2 RNAi - H00001573-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN6885 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6885 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02392 from Sigma-Aldrich
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CYP2J2 siRNA (Human) - CRH1105 from Cohesion Biosciences
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CYP2J2 - MBS8240428 from MyBioSource
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shRNA set against Human CYP2J2 (NM_000775.2) - SHH273349 from Creative biogene
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Human CYP2J2 siRNA - orb261607 from Biorbyt
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CYP2J2 shRNA Plasmid (Human) - CHH1105 from Cohesion Biosciences
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CYP2J2 miRNA 3'UTR clone - MiUTR1H-02625 from Creative biogene
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