| Gene Symbol |
CYP2J2
|
| Entrez Gene |
1573
|
| Alt Symbol |
CPJ2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 2, subfamily J, polypeptide 2
|
| Other Description |
CYPIIJ2|arachidonic acid epoxygenase|cytochrome P450 2J2|cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2|flavoprotein-linked monooxygenase|microsomal monooxygenase
|
| Swissprots |
P51589 B2RD33 Q8TF13
|
| Accessions |
AAK63192 AAM44456 AAQ93356 EAX06611 EAX06612 EAX06613 EAX06614 P51589 AB080265 BAB85489 AF144566 AAD30164 AK055088 AK315387 BAG37780 BC032594 AAH32594 DQ890862 ABM81788 DQ894017 ABM84943 U37143 AAC50370 XR_246240 XR_946558 NM_000775 NP_000766
|
| Function |
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney.
|
| Top Pathways |
Ovarian steroidogenesis, Inflammatory mediator regulation of TRP channels, Arachidonic acid metabolism, Linoleic acid metabolism
|