| Gene Symbol |
IQSEC1
|
| Entrez Gene |
9922
|
| Alt Symbol |
ARF-GEP100, ARFGEP100, BRAG2, GEP100
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
IQ motif and Sec7 domain 1
|
| Other Description |
ADP-ribosylation factors guanine nucleotide-exchange protein 100|ADP-ribosylation factors guanine nucleotide-exchange protein 2|IQ motif and SEC7 domain-containing protein 1|brefeldin A-resistant ARF-GEF2|brefeldin-resistant Arf-GEF 2 protein
|
| Swissprots |
Q96D85 O94863 Q6DN90
|
| Accessions |
CCO13748 EAW64147 EAW64148 Q6DN90 AB018306 BAA34483 AF055004 AK294525 BAG57736 AY653734 AAT72063 BC008088 BC010267 AAH10267 BC024645 BQ004209 HY052708 JF432314 ADZ15531 XM_011534304 XP_011532606 XM_011534305 XP_011532607 XM_011534306 XP_011532608 XM_011534307 XP_011532609 XM_011534308 XP_011532610 XM_011534309 XP_011532611 XM_011534310 XP_011532612 XM_011534311 XP_011532613 XM_011534312 XP_011532614 XM_011534313 XP_011532615 XM_011534314 XP_011532616 XM_011534315 XP_011532617 NM_001134382 NP_001127854 NM_014869 NP_055684
|
| Function |
Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. {ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11226253}. Nucleus {ECO:0000269|PubMed:11226253}. Note=At steady state, may be preferentially cytosolic.
|
| Tissue Specificity |
Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. {ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:9872452}.
|
| Top Pathways |
Endocytosis
|