IQSEC1

Gene Symbol IQSEC1
Entrez Gene 9922
Alt Symbol ARF-GEP100, ARFGEP100, BRAG2, GEP100
Species Human
Gene Type protein-coding
Description IQ motif and Sec7 domain 1
Other Description ADP-ribosylation factors guanine nucleotide-exchange protein 100|ADP-ribosylation factors guanine nucleotide-exchange protein 2|IQ motif and SEC7 domain-containing protein 1|brefeldin A-resistant ARF-GEF2|brefeldin-resistant Arf-GEF 2 protein
Swissprots Q96D85 O94863 Q6DN90
Accessions CCO13748 EAW64147 EAW64148 Q6DN90 AB018306 BAA34483 AF055004 AK294525 BAG57736 AY653734 AAT72063 BC008088 BC010267 AAH10267 BC024645 BQ004209 HY052708 JF432314 ADZ15531 XM_011534304 XP_011532606 XM_011534305 XP_011532607 XM_011534306 XP_011532608 XM_011534307 XP_011532609 XM_011534308 XP_011532610 XM_011534309 XP_011532611 XM_011534310 XP_011532612 XM_011534311 XP_011532613 XM_011534312 XP_011532614 XM_011534313 XP_011532615 XM_011534314 XP_011532616 XM_011534315 XP_011532617 NM_001134382 NP_001127854 NM_014869 NP_055684
Function Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. {ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11226253}. Nucleus {ECO:0000269|PubMed:11226253}. Note=At steady state, may be preferentially cytosolic.
Tissue Specificity Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. {ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:9872452}.
Top Pathways Endocytosis

BRAG2 CRISPR/Cas9 KO Plasmid (h) - sc-405433 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRAG2 HDR Plasmid (h) - sc-405433-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRAG2 Double Nickase Plasmid (h) - sc-405433-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRAG2 Double Nickase Plasmid (h2) - sc-405433-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRAG2 CRISPR Activation Plasmid (h) - sc-405433-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRAG2 CRISPR Activation Plasmid (h2) - sc-405433-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRAG2 Lentiviral Activation Particles (h) - sc-405433-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRAG2 Lentiviral Activation Particles (h2) - sc-405433-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRAG2 siRNA (h) - sc-78384 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BRAG2 shRNA Plasmid (h) - sc-78384-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BRAG2 shRNA (h) Lentiviral Particles - sc-78384-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU093961 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10756 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10756 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09754 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09754

IQSEC1 siRNA (Human) - CRH6667 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IQSEC1 - MBS8238255 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IQSEC1 (NM_014869.5) - SHH320441 from Creative biogene

Category siRNA
Species Reactivities Human

IQSEC1 shRNA Plasmid (Human) - CHH6667 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IQSEC1 miRNA 3'UTR clone - MiUTR4H-TG04568 from Creative biogene

Species Reactivities Human
Search more