IQSEC1

Gene Symbol IQSEC1
Entrez Gene 9922
Alt Symbol ARF-GEP100, ARFGEP100, BRAG2, GEP100
Species Human
Gene Type protein-coding
Description IQ motif and Sec7 domain 1
Other Description ADP-ribosylation factors guanine nucleotide-exchange protein 100|ADP-ribosylation factors guanine nucleotide-exchange protein 2|IQ motif and SEC7 domain-containing protein 1|brefeldin A-resistant ARF-GEF2|brefeldin-resistant Arf-GEF 2 protein
Swissprots Q96D85 O94863 Q6DN90
Accessions CCO13748 EAW64147 EAW64148 Q6DN90 AB018306 BAA34483 AF055004 AK294525 BAG57736 AY653734 AAT72063 BC008088 BC010267 AAH10267 BC024645 BQ004209 HY052708 JF432314 ADZ15531 XM_011534304 XP_011532606 XM_011534305 XP_011532607 XM_011534306 XP_011532608 XM_011534307 XP_011532609 XM_011534308 XP_011532610 XM_011534309 XP_011532611 XM_011534310 XP_011532612 XM_011534311 XP_011532613 XM_011534312 XP_011532614 XM_011534313 XP_011532615 XM_011534314 XP_011532616 XM_011534315 XP_011532617 NM_001134382 NP_001127854 NM_014869 NP_055684
Function Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. {ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11226253}. Nucleus {ECO:0000269|PubMed:11226253}. Note=At steady state, may be preferentially cytosolic.
Tissue Specificity Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. {ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:9872452}.
Top Pathways Endocytosis

BRAG2 (C-16) - sc-102347 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IQSEC1 antibody - ab122442 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122442, at a 1/50 dilution, staining IQSEC1 in paraffin embedded Human skin tissue by Immunohistochemistry.

Anti-IQSEC1 antibody - ab140929 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human tonsil (squamous epithelium) tissue labelling IQSEC1 with ab140929 at 5 µg/ml.

Anti-IQSEC1 Antibody IHC-plus™ - LS-B7818 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-IQSEC1 antibody IHC of human tonsil, squamous epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7818 dilution 5 ug/ml.

Anti-IQSEC1 Antibody (N-Terminus) IHC-plus™ - LS-B12159 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

IQSEC1 Antibody - NBP2-32654 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: IQSEC1 Antibody [NBP2-32654] - Staining of human spleen shows cytoplasmic positivity in immune cells.

IQSEC1 Antibody - NBP1-81480 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: IQSEC1 Antibody [NBP1-81480] - Immunofluorescent staining of human cell line A-431 shows localization to nucleoli & vesicles.

Anti-GEP100 antibody produced in rabbit - G4798 from Sigma-Aldrich

Prices $61.10, $360.00
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Whole extract of MDA-MB-231 cells was separated on SDS-PAGE and probed with Rabbit Anti-GEP100 (<B>Cat. No. G4798</B>). The antibody was developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. 1 μg/mL antibody<BR/>2. 1μg/mL antibody + GEP100 immunizing peptide (human, 832-846)

Anti-IQSEC1 antibody produced in rabbit - HPA038144 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-IQSEC1: <B>Cat. No. HPA038144</B>: Immunohistochemical staining of Human breast shows strong cytoplasmic and membranous positivity in glandular cells.

Anti-IQSEC1 antibody produced in rabbit - HPA038143 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-IQSEC1: <B>Cat. No. HPA038143</B>: Immunohistochemical staining of human skin shows strong cytoplasmic positivity in basal cells of squamous epitheium.

IQSEC1 antibody - 70R-18002 from Fitzgerald

Host Rabbit
Clonality Polyclonal

Rabbit Anti-Human IQSEC1 - 119-16700 from RayBiotech

Host Rabbit

IQSEC1 Antibody - 8009 from ProSci

Prices $79.00, $325.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of IQSEC1 in A20 cell lysate with IQSEC1 antibody at 1 μg/ml.

IQSEC1 antibody - 12743-1-AP from Proteintech Group

Host Rabbit
Clonality Polyclonal

IQ motif and Sec7 domain 1 , Polyclonal Antibody - MBS710641 from MyBioSource

Prices $375.00, $715.00
Sizes 50 µl, 150 µl
Host Rabbit
Clonality Polyclonal

IQSEC1, Polyclonal Antibody - MBS2517249 from MyBioSource

Prices $195.00, $270.00, $435.00
Sizes 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

IQSEC1, Polyclonal Antibody - MBS243814 from MyBioSource

Prices $495.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

IQSEC1, Polyclonal Antibody - MBS153501 from MyBioSource

Prices $140.00, $355.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal

IQSEC1 Antibody - EPP14436 from Elabscience

Prices $296.00, $485.00
Sizes 120 μl, 200 μl
Host Rabbit
Clonality Polyclonal

Rabbit anti-Human IQSEC1 polyclonal antibody - DPABH-02567 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-IQSEC1 (aa 28-96) polyclonal antibody - DPABH-20744 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

IQSEC1 Antibody - 600-401-BY9 from Rockland Immunochemicals Inc

Prices $319.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

IQSEC1 antibody - pab71526 from Covalab

Host Rabbit
Clonality Polyclonal

IQSEC1 Antibody (OALA06529) - OALA06529 from Aviva Systems Biology

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Search more