IQSEC1

Gene Symbol	IQSEC1
Entrez Gene	9922
Alt Symbol	ARF-GEP100, ARFGEP100, BRAG2, GEP100
Species	Human
Gene Type	protein-coding
Description	IQ motif and Sec7 domain 1
Other Description	ADP-ribosylation factors guanine nucleotide-exchange protein 100|ADP-ribosylation factors guanine nucleotide-exchange protein 2|IQ motif and SEC7 domain-containing protein 1|brefeldin A-resistant ARF-GEF2|brefeldin-resistant Arf-GEF 2 protein
Swissprots	Q96D85 O94863 Q6DN90
Accessions	CCO13748 EAW64147 EAW64148 Q6DN90 AB018306 BAA34483 AF055004 AK294525 BAG57736 AY653734 AAT72063 BC008088 BC010267 AAH10267 BC024645 BQ004209 HY052708 JF432314 ADZ15531 XM_011534304 XP_011532606 XM_011534305 XP_011532607 XM_011534306 XP_011532608 XM_011534307 XP_011532609 XM_011534308 XP_011532610 XM_011534309 XP_011532611 XM_011534310 XP_011532612 XM_011534311 XP_011532613 XM_011534312 XP_011532614 XM_011534313 XP_011532615 XM_011534314 XP_011532616 XM_011534315 XP_011532617 NM_001134382 NP_001127854 NM_014869 NP_055684
Function	Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. {ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11226253}. Nucleus {ECO:0000269|PubMed:11226253}. Note=At steady state, may be preferentially cytosolic.
Tissue Specificity	Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. {ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:9872452}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IQSEC1 cDNA (ANA11512) - ANA11512 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC010267

IQSEC1 cDNA (ANA11513) - ANA11513 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC010267

IQSEC1 cDNA (ANA11514) - ANA11514 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC010267

IQSEC1 - MBS1275146 from MyBioSource Species Human Accession BC010267

Human IQSEC1 ORF Clone(NM_001134382.2) - CDCL167363 from Creative Biomart Species Human Accession NM_001134382.2

Human IQSEC1 Gene ORF cDNA clone in cloning vector - HG15021-G from Sino Biological Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15021-ANG from Sino Biological Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15021-NF from Sino Biological Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15021-NY from Sino Biological Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid, N-His tag - HG15021-NH from Sino Biological Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15021-CF from Sino Biological Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15021-NM from Sino Biological Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15021-ACR from Sino Biological Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15021-CM from Sino Biological Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid - HG15021-UT from Sino Biological Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid, C-His tag - HG15021-CH from Sino Biological Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15021-CY from Sino Biological Species Human

Human IQSEC1 ORF Clone (BC010267) - CDCS413807 from Creative biogene Species Human Accession Q6DN90

Human IQSEC1 ORF clone (BC010267) - CDCB158508 from Creative biogene Species Human

Human IQSEC1 Gene cDNA Clone - orb143874 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15021-ACG from Sino Biological Species Human

Human IQSEC1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15021-ANR from Sino Biological Species Human

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