EHMT1

Gene Symbol EHMT1
Entrez Gene 79813
Alt Symbol EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KMT1D, bA188C12.1
Species Human
Gene Type protein-coding
Description euchromatic histone-lysine N-methyltransferase 1
Other Description G9a-like protein 1|H3-K9-HMTase 5|histone H3-K9 methyltransferase 5|histone-lysine N-methyltransferase EHMT1|histone-lysine N-methyltransferase, H3 lysine-9 specific 5|lysine N-methyltransferase 1D
Swissprots Q96KH4 B1AQ59 Q86X08 Q8TCN7 Q96JF1 Q96F53 B1AQ58 Q9H9B1
Accessions EAW88409 EAW88410 EAW88411 EAW88412 EAW88413 Q9H9B1 AB028932 BAB56104 AB058779 BAB47505 AF461894 AAQ04808 AK022941 BAB14321 AK309602 AL713772 CAD28534 AL832865 AY083210 AAM09024 BC011608 AAH11608 BC025772 AAH25772 BC047504 AAH47504 BM681619 BQ028833 CA426038 XM_005266105 XP_005266162 XM_005266110 XP_005266167 XM_006717288 XP_006717351 XM_011519021 XP_011517323 XM_011519022 XP_011517324 XM_011519023 XP_011517325 XM_011519024 XP_011517326 XM_011519025 XP_011517327 XM_011519026 XP_011517328 XM_011519027 XP_011517329 XM_011519028 XP_011517330 XM_011519029 XP_011517331 XM_011519030 XP_011517332 XM_011519031 XP_011517333 XM_011519032 XP_011517334 XM_011519033 XP_011517335 NM_001145527 NP_001138999 NM_024757 NP_079033
Function Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non- histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. {ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}.
Subcellular Location Nucleus. Chromosome. Note=Associates with euchromatic regions.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11347906}.
Top Pathways Lysine degradation

EHMT1 (N-16) - sc-68165 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EHMT1 (N-16): sc-68165. Western blot analysis of EHMT1 expression in K-562 nuclear extract.

EHMT1 (V-19) - sc-68166 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EHMT1 (V-19): sc-68166. Western blot analysis of EHMT1 expression in MES-SA/Dx5 whole cell lysate.

EHMT1 (T-22) - sc-130747 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
EHMT1 (T-22): sc-130747. Western blot analysis of EHMT1 expression in non-transfected (A) and human EHMT1 transfected (B) 293 whole cell lysates.

Anti-KMT1D / GLP / Eu HMTase1 antibody - ab63161 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KMT1D / GLP / Eu HMTase1 antibody (ab63161) at 1/50 dilutionLane 1 : 293 cell lysates nontransfectedLane 2 : 293 cell lysates transiently transfected with the KMT1D / GLP / Eu HMTase1 geneLysates/proteins at 2 µg per lane.

Anti-KMT1D / GLP / Eu HMTase1 antibody - ab84751 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84751 at 1/100 dilution staining KMT1D / GLP / Eu HMTase1 in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

Anti-KMT1D / GLP / Eu HMTase1 antibody - ab134768 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-KMT1D / GLP / Eu HMTase1 antibody (ab134768) at 1/1000 dilution + HeLa cell lysate

Anti-KMT1D / GLP / Eu HMTase1 antibody - ab135488 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KMT1D / GLP / Eu HMTase1 antibody (ab135488) at 1/100 dilutionLane 1 : 293 cell lysate, non-transfectedLane 2 : 293 cell lysate, transiently transfected with the KMT1D / GLP / Eu HMTase1 geneLysates/proteins at 2 µg per lane.

Anti-KMT1D / GLP / Eu HMTase1 antibody - ab200944 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-KMT1D / GLP / Eu HMTase1 antibody [B0422] - ChIP Grade - ab41969 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone B0422
Ab41969 at 5 µg/ml staining WT mouse ES cell (Positive)

Anti-KMT1D / GLP / Eu HMTase1 antibody - N-terminal - ab135484 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KMT1D / GLP / Eu HMTase1 antibody - N-terminal (ab135484) at 1/50 dilutionLane 1 : 293 cell lysate, non-transfectedLane 2 : 293 cell lysate, transiently transfected with the KMT1D / GLP / Eu HMTase1 geneLysates/proteins at 2 µg per lane.

Anti-KMT1D / GLP / Eu HMTase1 antibody - N-terminal - ab135487 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KMT1D / GLP / Eu HMTase1 antibody - N-terminal (ab135487) at 1/100 dilutionLane 1 : Non-transfected 293 cell lysateLane 2 : 293 cell lysate transiently transfected with the KMT1D / GLP / Eu HMTase1 geneLysates/proteins at 2 µg per lane.

Anti-EHMT1 Antibody (aa175-225) - LS-C121207 from LifeSpan Bioscience

Prices $665.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EHMT1 Antibody (aa203-233) - LS-C96519 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of EHMT1 (arrow) using rabbit polyclonal EHMT1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EHMT1 gene (Lane 2) (Origene Technologies).

Anti-EHMT1 Antibody (Biotin) - LS-C180716 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EHMT1 Antibody (DY650) - LS-C180717 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EHMT1 Antibody (DY488) - LS-C180718 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EHMT1 Antibody (aa367-396) - LS-C96521 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of EHMT1 (arrow) using rabbit polyclonal EHMT1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EHMT1 gene (Lane 2) (Origene Technologies).

Anti-EHMT1 Antibody (aa1145-1174) - LS-C96520 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of EHMT1 (arrow) using rabbit polyclonal EHMT1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EHMT1 gene (Lane 2) (Origene Technologies).

Anti-EHMT1 Antibody (DY550) - LS-C180719 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EHMT1 Antibody (aa195-226) - LS-C96615 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of EUHMTASE (arrow) using rabbit polyclonal EHMT1 (EUHMTASE1) Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EUHMTASE gene (Lane 2) (Origene Technologies).

Anti-EHMT1 Antibody (aa979-1010) - LS-C96616 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of EUHMTASE (arrow) using rabbit polyclonal EHMT1 (EUHMTASE1) Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EUHMTASE gene (Lane 2) (Origene Technologies).

Anti-EHMT1 Antibody (clone C7-5) - LS-C179472 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal
Clone C7-5

Anti-EHMT1 Antibody (N-Terminus, FITC) - LS-C277199 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EHMT1 Antibody (N-Terminus, AP) - LS-C277196 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EHMT1 Antibody (N-Terminus, APC) - LS-C277198 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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