EHMT1

Gene Symbol EHMT1
Entrez Gene 79813
Alt Symbol EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KMT1D, bA188C12.1
Species Human
Gene Type protein-coding
Description euchromatic histone-lysine N-methyltransferase 1
Other Description G9a-like protein 1|H3-K9-HMTase 5|histone H3-K9 methyltransferase 5|histone-lysine N-methyltransferase EHMT1|histone-lysine N-methyltransferase, H3 lysine-9 specific 5|lysine N-methyltransferase 1D
Swissprots Q96KH4 B1AQ59 Q86X08 Q8TCN7 Q96JF1 Q96F53 B1AQ58 Q9H9B1
Accessions EAW88409 EAW88410 EAW88411 EAW88412 EAW88413 Q9H9B1 AB028932 BAB56104 AB058779 BAB47505 AF461894 AAQ04808 AK022941 BAB14321 AK309602 AL713772 CAD28534 AL832865 AY083210 AAM09024 BC011608 AAH11608 BC025772 AAH25772 BC047504 AAH47504 BM681619 BQ028833 CA426038 XM_005266105 XP_005266162 XM_005266110 XP_005266167 XM_006717288 XP_006717351 XM_011519021 XP_011517323 XM_011519022 XP_011517324 XM_011519023 XP_011517325 XM_011519024 XP_011517326 XM_011519025 XP_011517327 XM_011519026 XP_011517328 XM_011519027 XP_011517329 XM_011519028 XP_011517330 XM_011519029 XP_011517331 XM_011519030 XP_011517332 XM_011519031 XP_011517333 XM_011519032 XP_011517334 XM_011519033 XP_011517335 NM_001145527 NP_001138999 NM_024757 NP_079033
Function Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non- histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. {ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}.
Subcellular Location Nucleus. Chromosome. Note=Associates with euchromatic regions.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11347906}.
Top Pathways Lysine degradation

EHMT1 CRISPR/Cas9 KO Plasmid (h) - sc-402460 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHMT1 HDR Plasmid (h) - sc-402460-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHMT1 Double Nickase Plasmid (h) - sc-402460-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHMT1 Double Nickase Plasmid (h2) - sc-402460-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHMT1 CRISPR Activation Plasmid (h) - sc-402460-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHMT1 CRISPR Activation Plasmid (h2) - sc-402460-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHMT1 Lentiviral Activation Particles (h) - sc-402460-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHMT1 Lentiviral Activation Particles (h2) - sc-402460-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHMT1 siRNA (h) - sc-62261 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EHMT1 shRNA Plasmid (h) - sc-62261-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EHMT1 shRNA (h) Lentiviral Particles - sc-62261-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GLP/EHMT1 RNAi - H00079813-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU080641 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7728 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7728 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12560 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12560

EHMT1 siRNA (Human) - CRJ2583 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EHMT1 - MBS8200056 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EHMT1 CRISPR/Cas9 KO Plasmid (h2) - sc-402460-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHMT1 HDR Plasmid (h2) - sc-402460-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human EHMT1 (NM_024757.4) - SHH284045 from Creative biogene

Category siRNA
Species Reactivities Human

EHMT1 shRNA Plasmid (Human) - CHJ2583 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EHMT1 miRNA 3'UTR clone - MiUTR3H-08893 from Creative biogene

Species Reactivities Human

EHMT1 miRNA 3'UTR clone - MiUTR3H-08894 from Creative biogene

Species Reactivities Human
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