EHMT1

Gene Symbol	EHMT1
Entrez Gene	79813
Alt Symbol	EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KMT1D, bA188C12.1
Species	Human
Gene Type	protein-coding
Description	euchromatic histone-lysine N-methyltransferase 1
Other Description	G9a-like protein 1|H3-K9-HMTase 5|histone H3-K9 methyltransferase 5|histone-lysine N-methyltransferase EHMT1|histone-lysine N-methyltransferase, H3 lysine-9 specific 5|lysine N-methyltransferase 1D
Swissprots	Q96KH4 B1AQ59 Q86X08 Q8TCN7 Q96JF1 Q96F53 B1AQ58 Q9H9B1
Accessions	EAW88409 EAW88410 EAW88411 EAW88412 EAW88413 Q9H9B1 AB028932 BAB56104 AB058779 BAB47505 AF461894 AAQ04808 AK022941 BAB14321 AK309602 AL713772 CAD28534 AL832865 AY083210 AAM09024 BC011608 AAH11608 BC025772 AAH25772 BC047504 AAH47504 BM681619 BQ028833 CA426038 XM_005266105 XP_005266162 XM_005266110 XP_005266167 XM_006717288 XP_006717351 XM_011519021 XP_011517323 XM_011519022 XP_011517324 XM_011519023 XP_011517325 XM_011519024 XP_011517326 XM_011519025 XP_011517327 XM_011519026 XP_011517328 XM_011519027 XP_011517329 XM_011519028 XP_011517330 XM_011519029 XP_011517331 XM_011519030 XP_011517332 XM_011519031 XP_011517333 XM_011519032 XP_011517334 XM_011519033 XP_011517335 NM_001145527 NP_001138999 NM_024757 NP_079033
Function	Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non- histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. {ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}.
Subcellular Location	Nucleus. Chromosome. Note=Associates with euchromatic regions.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:11347906}.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EHMT1 Antibody Blocking Peptide - LS-E99 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EHMT1 Antibody Blocking Peptide - LS-E100 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EHMT1 Antibody Blocking Peptide - LS-E464 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EHMT1 Antibody Blocking Peptide - LS-E465 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GLP/EHMT1 Protein - H00079813-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human GLP/EHMT1 Protein - H00079813-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

GLP/EHMT1 Peptide - P0155 from Novus Biologicals Category Peptide Species Human

GLP/EHMT1 Peptide - P0154 from Novus Biologicals Category Peptide Species Human

EHMT1-Antibody-C-term-Blocking-Peptide - BP1018b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EHMT1-Antibody-N-term-Blocking-Peptide - BP1018a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EHMT1-EUHMTASE1-Antibody-Center-Blocking-peptide - BP1074b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EHMT1-EUHMTASE1-Antibody-N-term-Blocking-peptide - BP1074a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EHMT1 - H00079813-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

EHMT1 - H00079813-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EHMT1 - H00079813-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human Euchromatic Histone-lysine N-methyltransferase 1 - EHMT1-293H from Creative Biomart Category Protein Source Human

Recombinant Human Euchromatic Histone-lysine N-methyltransferase 1 - EHMT1-294H from Creative Biomart Category Protein Source Human

Recombinant Human EHMT1, His-tagged - EHMT1-27743TH from Creative Biomart Category Protein Source E. coli

Recombinant Human Histone-lysine N-methyltransferase EHMT1(EHMT1) ,partial - CSB-YP862048HU CSB-EP862048HU CSB-BP862048HU CSB-MP862048HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EHMT1 Protein - abx163571 from Abbexa Category Protein Species Human, Mouse, Rat

Recombinant Human EHMT1 Protein, GST-tagged - EHMT1-88H from Creative Biomart Category Protein Source E. coli Species Human

EHMT1-Blocking-Peptide-Center - BP1018c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EHMT1 Peptide, Human - M34GP04784H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant EHMT1 (894-1298) protein - 31520 from ActiveMotif Category Protein Prices $395.00, $2,900.00 Sizes 50 µg, 1 mg Source E. coli Species Human

GLP/EHMT1 Recombinant Protein Antigen - NBP2-57166PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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