| Gene Symbol |
EHMT1
|
| Entrez Gene |
79813
|
| Alt Symbol |
EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KMT1D, bA188C12.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
euchromatic histone-lysine N-methyltransferase 1
|
| Other Description |
G9a-like protein 1|H3-K9-HMTase 5|histone H3-K9 methyltransferase 5|histone-lysine N-methyltransferase EHMT1|histone-lysine N-methyltransferase, H3 lysine-9 specific 5|lysine N-methyltransferase 1D
|
| Swissprots |
Q96KH4 B1AQ59 Q86X08 Q8TCN7 Q96JF1 Q96F53 B1AQ58 Q9H9B1
|
| Accessions |
EAW88409 EAW88410 EAW88411 EAW88412 EAW88413 Q9H9B1 AB028932 BAB56104 AB058779 BAB47505 AF461894 AAQ04808 AK022941 BAB14321 AK309602 AL713772 CAD28534 AL832865 AY083210 AAM09024 BC011608 AAH11608 BC025772 AAH25772 BC047504 AAH47504 BM681619 BQ028833 CA426038 XM_005266105 XP_005266162 XM_005266110 XP_005266167 XM_006717288 XP_006717351 XM_011519021 XP_011517323 XM_011519022 XP_011517324 XM_011519023 XP_011517325 XM_011519024 XP_011517326 XM_011519025 XP_011517327 XM_011519026 XP_011517328 XM_011519027 XP_011517329 XM_011519028 XP_011517330 XM_011519029 XP_011517331 XM_011519030 XP_011517332 XM_011519031 XP_011517333 XM_011519032 XP_011517334 XM_011519033 XP_011517335 NM_001145527 NP_001138999 NM_024757 NP_079033
|
| Function |
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non- histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. {ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}.
|
| Subcellular Location |
Nucleus. Chromosome. Note=Associates with euchromatic regions.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:11347906}.
|
| Top Pathways |
Lysine degradation
|