FNBP1

Gene Symbol FNBP1
Entrez Gene 23048
Alt Symbol FBP17
Species Human
Gene Type protein-coding
Description formin binding protein 1
Other Description formin-binding protein 1|formin-binding protein 17
Swissprots Q5TC87 B7ZL12 Q6P658 Q9NWD1 O60301 Q9H8H8 Q7LGG2 Q96RU3 E9PGQ4 Q3MIN8 Q5TC88
Accessions EAW87916 EAW87917 EAW87918 EAW87919 Q96RU3 AB011126 BAA25480 AF265550 AAK49824 AK000975 BAA91451 AK001616 AK023681 BAB14638 AK090963 AK293743 BAG57166 AL049935 AW575478 AY952886 BC009262 BC018159 BC062463 AAH62463 BC101755 AAI01756 BC143513 AAI43514 BC143514 AAI43515 BC143515 AAI43516 CK005680 XM_005251815 XP_005251872 XM_005251820 XP_005251877 XM_005251821 XP_005251878 XM_005251822 XP_005251879 XM_005251823 XP_005251880 XM_005251824 XP_005251881 XM_005251825 XP_005251882 XM_005251826 XP_005251883 XM_005251827 XP_005251884 XM_005251828 XP_005251885 XM_005251829 XP_005251886 XM_005251830 XP_005251887 XM_005251831 XP_005251888 XM_005251832 XP_005251889 XM_005251833 XP_005251890 XM_005251834 XP_005251891 XM_006717016 XP_006717079 XM_011518399 XP_011516701 XM_011518400 XP_011516702 XM_011518401 XP_011516703 XM_011518402 XP_011516704 XM_011518403 XP_011516705 NM_015033 NP_055848
Function May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}.
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
Tissue Specificity Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain. {ECO:0000269|PubMed:11438682, ECO:0000269|PubMed:15252009}.

FNBP1 (Q-13) - sc-82149 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FNBP1 (Q-13): sc-82149. Western blot analysis of FNBP1 expression in K-562 whole cell lysate.

FNBP1 (N-13) - sc-82148 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

FNBP1 (E-19) - sc-82147 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FNBP1 (E-19): sc-82147. Western blot analysis of FNBP1 expression in human ovary (A), human stomach (B) and human bladder (C) tissue extracts.

Anti-FBP17 antibody - ab113961 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical staining of Human Small Intestine using ab113961 at 3.75µg/ml

Anti-FBP17 antibody - ab150577 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Formalin-fixed, Paraffin-embedded Human brain, cortex neurons, tissue labeling FBP17 with ab150577 at 10ug/ml.

Anti-FBP17 antibody - ab23934 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-FBP17 antibody (ab23934) at 0.25 µg/ml + Human Testis lysate (RIPA buffer, 35µg total protein per lane).

Anti-FBP17 antibody - ab100918 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FBP17 antibody (ab100918) at 0.1 µg/mlLane 1 : HeLa Whole Cell Lysate at 50 µgLane 2 : HeLa Whole Cell Lysate at 15 µgLane 3 : HeLa Whole Cell Lysate at 5 µgLane 4 : 293T Whole Cell Lysate at 50 µg

Anti-FBP17 antibody - ab100920 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FBP17 antibody (ab100920) at 0.4 µg/mlLane 1 : HeLa Whole Cell Lysate at 50 µgLane 2 : HeLa Whole Cell Lysate at 15 µgLane 3 : HeLa Whole Cell Lysate at 5 µgLane 4 : 293T Whole Cell Lysate at 50 µg

Anti-FBP17 antibody - ab118715 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FBP17 antibody (ab118715) at 1 µg/ml + Mouse pancreas lysate at 10 µgSecondaryGoat anti-Rabbit IgG-HRP

Anti-FBP17 antibody - ab72048 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Human brain tissue labelling FBP17 with ab72048 at 10µg/ml. Staining was enhanced by boiling tissue sections in 10mM sodium citrate buffer, pH6.0 for 10-20 minutes followed by cooling at room temperature for 20 minutes.

Anti-FNBP1 / FBP17 Antibody (aa132-145) IHC-plus™ - LS-B4929 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-FNBP1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4929 concentration 3.75 ug/ml.

Anti-FNBP1 / FBP17 Antibody (aa30-80) - LS-C143850 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FNBP1 / FBP17 Antibody (aa567-617) - LS-C289506 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FNBP1 / FBP17 Antibody (aa350-400) - LS-C289504 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FNBP1 / FBP17 Antibody (N-Terminus) - LS-C145864 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FNBP1 antibody LS-C145864 Western blot of Mouse Pancreas lysate. Antibody concentration 1 ug/ml.

Anti-FNBP1 / FBP17 Antibody (aa575-625) - LS-C148686 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of FNBP1 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top) and LS-C148686 (bottom) at 5 ug/ml.

Anti-FNBP1 / FBP17 Antibody (aa30-80) IHC-plus™ - LS-B7948 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FNBP1 / FBP17 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7948 dilution 10 ug/ml.

FNBP1 Antibody - NBP2-24526 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal

FNBP1 Antibody - NBP2-27082 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: FNBP1 Antibody [NBP2-27082] - analysis of FNBP1 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top) and this antibody (bottom) at 5 ug/ml.

FNBP1 Antibody - NBP2-16513 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FNBP1 Antibody [NBP2-16513] - Sample (30 ug of whole cell lysate) A: PC-12 7. 5% SDS PAGE gel, diluted at 1:2000.

FNBP1 Antibody - NB100-1457 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: FNBP1 Antibody [NB100-1457] - (0.25ug/ml) of human testis lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

FNBP1 Antibody - NBP1-47261 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FNBP1 Antibody [NBP1-47261] - Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-FBP17 antibody NBP1-47261 used for WB at 0.4 ug/ml (A) and 1 ug/ml (B) and used for IP at 10 ug/mg lysate. FBP17 was also immunoprecipitated by rabbit anti-FBP17 antibody NBP1-47260, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A and B).

FNBP1 Antibody - NBP1-47260 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FNBP1 Antibody [NBP1-47260] - Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-FBP17 antibody NBP1-47260 used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 10 ug/mg lysate. FBP17 was also immunoprecipitated by rabbit anti-FBP17 antibody NBP1-47261, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B).

FBP17 Polyclonal Antibody - bs-13147R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FBP17 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13147R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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