| Gene Symbol |
FNBP1
|
| Entrez Gene |
23048
|
| Alt Symbol |
FBP17
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
formin binding protein 1
|
| Other Description |
formin-binding protein 1|formin-binding protein 17
|
| Swissprots |
Q5TC87 B7ZL12 Q6P658 Q9NWD1 O60301 Q9H8H8 Q7LGG2 Q96RU3 E9PGQ4 Q3MIN8 Q5TC88
|
| Accessions |
EAW87916 EAW87917 EAW87918 EAW87919 Q96RU3 AB011126 BAA25480 AF265550 AAK49824 AK000975 BAA91451 AK001616 AK023681 BAB14638 AK090963 AK293743 BAG57166 AL049935 AW575478 AY952886 BC009262 BC018159 BC062463 AAH62463 BC101755 AAI01756 BC143513 AAI43514 BC143514 AAI43515 BC143515 AAI43516 CK005680 XM_005251815 XP_005251872 XM_005251820 XP_005251877 XM_005251821 XP_005251878 XM_005251822 XP_005251879 XM_005251823 XP_005251880 XM_005251824 XP_005251881 XM_005251825 XP_005251882 XM_005251826 XP_005251883 XM_005251827 XP_005251884 XM_005251828 XP_005251885 XM_005251829 XP_005251886 XM_005251830 XP_005251887 XM_005251831 XP_005251888 XM_005251832 XP_005251889 XM_005251833 XP_005251890 XM_005251834 XP_005251891 XM_006717016 XP_006717079 XM_011518399 XP_011516701 XM_011518400 XP_011516702 XM_011518401 XP_011516703 XM_011518402 XP_011516704 XM_011518403 XP_011516705 NM_015033 NP_055848
|
| Function |
May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
|
| Tissue Specificity |
Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain. {ECO:0000269|PubMed:11438682, ECO:0000269|PubMed:15252009}.
|