FNBP1

Gene Symbol FNBP1
Entrez Gene 23048
Alt Symbol FBP17
Species Human
Gene Type protein-coding
Description formin binding protein 1
Other Description formin-binding protein 1|formin-binding protein 17
Swissprots Q5TC87 B7ZL12 Q6P658 Q9NWD1 O60301 Q9H8H8 Q7LGG2 Q96RU3 E9PGQ4 Q3MIN8 Q5TC88
Accessions EAW87916 EAW87917 EAW87918 EAW87919 Q96RU3 AB011126 BAA25480 AF265550 AAK49824 AK000975 BAA91451 AK001616 AK023681 BAB14638 AK090963 AK293743 BAG57166 AL049935 AW575478 AY952886 BC009262 BC018159 BC062463 AAH62463 BC101755 AAI01756 BC143513 AAI43514 BC143514 AAI43515 BC143515 AAI43516 CK005680 XM_005251815 XP_005251872 XM_005251820 XP_005251877 XM_005251821 XP_005251878 XM_005251822 XP_005251879 XM_005251823 XP_005251880 XM_005251824 XP_005251881 XM_005251825 XP_005251882 XM_005251826 XP_005251883 XM_005251827 XP_005251884 XM_005251828 XP_005251885 XM_005251829 XP_005251886 XM_005251830 XP_005251887 XM_005251831 XP_005251888 XM_005251832 XP_005251889 XM_005251833 XP_005251890 XM_005251834 XP_005251891 XM_006717016 XP_006717079 XM_011518399 XP_011516701 XM_011518400 XP_011516702 XM_011518401 XP_011516703 XM_011518402 XP_011516704 XM_011518403 XP_011516705 NM_015033 NP_055848
Function May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}.
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
Tissue Specificity Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain. {ECO:0000269|PubMed:11438682, ECO:0000269|PubMed:15252009}.

FNBP1 CRISPR/Cas9 KO Plasmid (h) - sc-407064 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FNBP1 HDR Plasmid (h) - sc-407064-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FNBP1 Double Nickase Plasmid (h) - sc-407064-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FNBP1 Double Nickase Plasmid (h2) - sc-407064-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FNBP1 CRISPR Activation Plasmid (h) - sc-407064-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FNBP1 CRISPR Activation Plasmid (h2) - sc-407064-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FNBP1 Lentiviral Activation Particles (h) - sc-407064-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FNBP1 Lentiviral Activation Particles (h2) - sc-407064-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FNBP1 siRNA (h) - sc-75048 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FNBP1 shRNA Plasmid (h) - sc-75048-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FNBP1 shRNA (h) Lentiviral Particles - sc-75048-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FNBP1 RNAi - H00023048-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU090931 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8851 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8851 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FNBP1 siRNA (Human) - CRH7959 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FNBP1 - MBS8200311 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FNBP1 (NM_015033.2) - SHH296062 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FNBP1(NM_015033.2) - SHH064667 from Creative biogene

Category siRNA
Species Reactivities Human

FNBP1 shRNA Plasmid (Human) - CHH7959 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FNBP1 miRNA 3'UTR clone - MiUTR1H-03791 from Creative biogene

Species Reactivities Human
Search more