FNBP1

Gene Symbol	FNBP1
Entrez Gene	23048
Alt Symbol	FBP17
Species	Human
Gene Type	protein-coding
Description	formin binding protein 1
Other Description	formin-binding protein 1|formin-binding protein 17
Swissprots	Q5TC87 B7ZL12 Q6P658 Q9NWD1 O60301 Q9H8H8 Q7LGG2 Q96RU3 E9PGQ4 Q3MIN8 Q5TC88
Accessions	EAW87916 EAW87917 EAW87918 EAW87919 Q96RU3 AB011126 BAA25480 AF265550 AAK49824 AK000975 BAA91451 AK001616 AK023681 BAB14638 AK090963 AK293743 BAG57166 AL049935 AW575478 AY952886 BC009262 BC018159 BC062463 AAH62463 BC101755 AAI01756 BC143513 AAI43514 BC143514 AAI43515 BC143515 AAI43516 CK005680 XM_005251815 XP_005251872 XM_005251820 XP_005251877 XM_005251821 XP_005251878 XM_005251822 XP_005251879 XM_005251823 XP_005251880 XM_005251824 XP_005251881 XM_005251825 XP_005251882 XM_005251826 XP_005251883 XM_005251827 XP_005251884 XM_005251828 XP_005251885 XM_005251829 XP_005251886 XM_005251830 XP_005251887 XM_005251831 XP_005251888 XM_005251832 XP_005251889 XM_005251833 XP_005251890 XM_005251834 XP_005251891 XM_006717016 XP_006717079 XM_011518399 XP_011516701 XM_011518400 XP_011516702 XM_011518401 XP_011516703 XM_011518402 XP_011516704 XM_011518403 XP_011516705 NM_015033 NP_055848
Function	May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}.
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
Tissue Specificity	Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain. {ECO:0000269|PubMed:11438682, ECO:0000269|PubMed:15252009}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FBP17 peptide - ab45618 from Abcam Category Peptide Species Human

Human FBP17 protein fragment - ab161515 from Abcam Category Protein Source Wheat germ Species Human

FNBP1 / FBP17 Antibody Blocking Peptide - LS-E14954 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FNBP1 / FBP17 Antibody Blocking Peptide - LS-E25769 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FNBP1 Protein - H00023048-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FBP17/FNBP1 blocking peptide - GTX89672-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

FNBP1 Immunizing peptide - orb17406 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

FBP17 Peptide - AC21-0598-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Formin-binding protein 1 - H00023048-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Formin-binding protein 1 - H00023048-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FBP17 Peptide - 45-572P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Formin Binding Protein 1 (FNBP1) - RPC483Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Formin Binding Protein 1 (FNBP1) - RPC483Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Formin-binding protein 1(FNBP1) - CSB-YP822300HU CSB-EP822300HU CSB-BP822300HU CSB-MP822300HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Formin-binding protein 1 - TP311011 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

FBP17/FNBP1, Peptide - MBS426462 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

FNBP1 Recombinant Protein Antigen - NBP2-48556PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

FNBP1 Recombinant Protein Antigen - NBP2-48542PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

FNBP1-Antibody-C-term-Blocking-Peptide - BP5123b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FNBP1 Peptide, Human - M34GP05808H from Creative Peptides Category Peptide Source Synthetic. Species Human

Formin Binding Protein 1, Recombinant Protein - MBS2030447 from MyBioSource Category Protein Prices $185.00, $390.00, $605.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Formin-binding protein 1 (FNBP1), Recombinant Protein - MBS1328590 from MyBioSource Category Protein Prices $1,410.00, $1,410.00, $1,640.00, $1,640.00, $2,385.00, $2,385.00, $2,830.00, $2,830.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

FNBP1 Recombinant Protein (OPCD03281) - OPCD03281 from Aviva Systems Biology Category Protein Source E.coli Species Human

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