| Gene Symbol |
CHM
|
| Entrez Gene |
1121
|
| Alt Symbol |
DXS540, GGTA, HSD-32, REP-1, TCD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
choroideremia (Rab escort protein 1)
|
| Other Description |
rab proteins geranylgeranyltransferase component A 1
|
| Swissprots |
O43732 A1L4D2 P24386
|
| Accessions |
AAD13814 CAV30743 EAW98559 P24386 AK095883 BAC04640 AK291160 BAF83849 AK299323 BAG61331 AK312443 AY255796 AAP15253 BC032237 BC063522 BC065702 AAH65702 BC073987 AAH73987 BC105969 AAI05970 BC130494 AAI30495 BC130496 AAI30497 BC156457 AAI56458 BC172532 AAI72532 M83773 AAA61032 S60753 AAD14934 X57637 CAA40855 X78121 CAA55011 XM_006724615 XP_006724678 XM_011530839 XP_011529141 NM_000390 NP_000381 NM_001145414 NP_001138886 NM_001037312
|
| Function |
Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. {ECO:0000269|PubMed:18532927, ECO:0000269|PubMed:7957092}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:7957092}.
|