CHM

Gene Symbol CHM
Entrez Gene 1121
Alt Symbol DXS540, GGTA, HSD-32, REP-1, TCD
Species Human
Gene Type protein-coding
Description choroideremia (Rab escort protein 1)
Other Description rab proteins geranylgeranyltransferase component A 1
Swissprots O43732 A1L4D2 P24386
Accessions AAD13814 CAV30743 EAW98559 P24386 AK095883 BAC04640 AK291160 BAF83849 AK299323 BAG61331 AK312443 AY255796 AAP15253 BC032237 BC063522 BC065702 AAH65702 BC073987 AAH73987 BC105969 AAI05970 BC130494 AAI30495 BC130496 AAI30497 BC156457 AAI56458 BC172532 AAI72532 M83773 AAA61032 S60753 AAD14934 X57637 CAA40855 X78121 CAA55011 XM_006724615 XP_006724678 XM_011530839 XP_011529141 NM_000390 NP_000381 NM_001145414 NP_001138886 NM_001037312
Function Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. {ECO:0000269|PubMed:18532927, ECO:0000269|PubMed:7957092}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:7957092}.

REP-1 (2F1) - sc-23905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
REP-1 (2F1): sc-23905. Western blot analysis of REP-1 expression in Y79 whole cell lysate.

REP-1 (N-17) - sc-14759 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
REP-1 (N-17): sc-14759. Western blot analysis of REP-1 expression in A-431 whole cell lysate.

REP-1 (I-19) - sc-14761 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CHM antibody - ab10085 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CHM antibody - ab156186 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CHM antibody (ab156186) at 1/100 dilution + 293 cell lysate at 35 µg

Anti-CHM antibody [EPR7142] - ab134964 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7142
All lanes : Anti-CHM antibody [EPR7142] (ab134964) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Y79 cell lysateLane 3 : A431 cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CHM antibody - N-terminal - ab192454 from Abcam

Host Goat
Clonality Polyclonal
All lanes : Anti-CHM antibody - N-terminal (ab192454) at 1/1000 dilutionLane 1 : HEK293 cells transfected with VS-REP1Lane 2 : HEK293 cells transfected with AtT20Lysates/proteins at 100 µg per lane.SecondaryRabbit polyclonal anti goat IgG (HRP) at 1/10000 dilution

Anti-CHM / REP1 Antibody (aa164-180) - LS-C3021 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHM / REP1 Antibody (aa151-168) - LS-C3020 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHM / REP1 Antibody (aa292-320, APC) - LS-C254744 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHM / REP1 Antibody (aa292-320, AP) - LS-C254745 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHM / REP1 Antibody (aa292-320, PE) - LS-C254750 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHM / REP1 Antibody (aa292-320, Biotin) - LS-C254746 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHM / REP1 Antibody (aa292-320, Azide-free, HRP) - LS-C254748 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHM / REP1 Antibody (aa292-320, FITC) - LS-C254747 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHM / REP1 Antibody (aa292-320) - LS-C320357 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHM / REP1 Antibody (aa35-84) - LS-C112319 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CHM antibody LS-C112319 Western blot of Fetal Thymus lysate. Antibody concentration 1 ug/ml.

Anti-CHM / REP1 Antibody (aa292-320) - LS-C157638 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
CHM Antibody western blot of 293 cell line lysates (35 ug/lane). The CHM antibody detected the CHM protein (arrow).

Anti-CHM / REP1 Antibody (aa1-80) - LS-C204229 from LifeSpan Bioscience

Prices $355.00
Sizes 600 µg
Host Goat
Clonality Polyclonal
Western blot. Anti-REP1 antibody at 1:1000 dilution. HEK293 cells transfected with V5-REP1 and AtT20 cells. Lysates at 100 ug per lane. Rabbit polyclonal to goat IgG (HRP) at 1:10000 dilution.

Anti-CHM / REP1 Antibody (Internal, clone EPR7142) IHC-plus™ - LS-B8700 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7142
Anti-CHM / REP1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CHM Antibody - NBP1-84954 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: CHM Antibody [NBP1-84954] - Staining of human pancreas shows cytoplasmic positivity in exocrine glandular cells.

CHM Antibody - NBP1-79946 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CHM Antibody [NBP1-79946] - Human Thymus lysate, concentration 0.2-1 ug/ml.

Anti-CHM, (N-terminal) antibody produced in rabbit - SAB2104179 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CHM, antibody produced in rabbit: <B>Cat. No. SAB2104179</B>: Immunoblotting analysis of CHM in fetal thymus tissue lysate with CHM anitbody at 1 μg/mL.

CHM antibody - N-terminal region (AVARP13011_P050) - AVARP13011_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CHM-Antibody-Center - AP20084c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
CHM Antibody (Center) (Cat. #AP20084c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CHM antibody detected the CHM protein (arrow).
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