CHM

Gene Symbol	CHM
Entrez Gene	1121
Alt Symbol	DXS540, GGTA, HSD-32, REP-1, TCD
Species	Human
Gene Type	protein-coding
Description	choroideremia (Rab escort protein 1)
Other Description	rab proteins geranylgeranyltransferase component A 1
Swissprots	O43732 A1L4D2 P24386
Accessions	AAD13814 CAV30743 EAW98559 P24386 AK095883 BAC04640 AK291160 BAF83849 AK299323 BAG61331 AK312443 AY255796 AAP15253 BC032237 BC063522 BC065702 AAH65702 BC073987 AAH73987 BC105969 AAI05970 BC130494 AAI30495 BC130496 AAI30497 BC156457 AAI56458 BC172532 AAI72532 M83773 AAA61032 S60753 AAD14934 X57637 CAA40855 X78121 CAA55011 XM_006724615 XP_006724678 XM_011530839 XP_011529141 NM_000390 NP_000381 NM_001145414 NP_001138886 NM_001037312
Function	Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. {ECO:0000269|PubMed:18532927, ECO:0000269|PubMed:7957092}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:7957092}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

REP-1 CRISPR/Cas9 KO Plasmid (h) - sc-404025 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

REP-1 HDR Plasmid (h) - sc-404025-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

REP-1 Double Nickase Plasmid (h) - sc-404025-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

REP-1 Double Nickase Plasmid (h2) - sc-404025-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

REP-1 CRISPR Activation Plasmid (h) - sc-404025-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

REP-1 CRISPR Activation Plasmid (h2) - sc-404025-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

REP-1 Lentiviral Activation Particles (h) - sc-404025-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

REP-1 Lentiviral Activation Particles (h2) - sc-404025-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

REP-1 siRNA (h) - sc-41804 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

REP-1 shRNA Plasmid (h) - sc-41804-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

REP-1 shRNA (h) Lentiviral Particles - sc-41804-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CHM RNAi - H00001121-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CHM RNAi - H00001121-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU097661 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® esiRNA - EHU100091 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6066 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6066 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR14065 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr14065

CHM siRNA (Human) - CRH0801 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CHM - MBS8203392 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CHM (NM_000390.2) - SHH263141 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human CHM(NM_000390.2) - SHG175375 from Creative biogene Category siRNA Species Reactivities Human

Human CHM siRNA - orb261303 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CHM shRNA Plasmid (Human) - CHH0801 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CHM miRNA 3'UTR clone - MiUTR1H-02122 from Creative biogene Species Reactivities Human

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