IFNL3

Gene Symbol	IFNL3
Entrez Gene	282617
Alt Symbol	IL-28B, IL28B, IL28C
Species	Human
Gene Type	protein-coding
Description	interferon, lambda 3
Other Description	IFN-lambda-3|IFN-lambda-4|IL-28C|cytokine Zcyto22|interferon lambda-3|interferon lambda-4|interferon, lambda 4|interleukin 28B (interferon, lambda 3)|interleukin 28C|interleukin-28B|interleukin-28C
Swissprots	A2BDE1 Q8IWL6 Q7Z4J3 Q6VN56 Q8IZI9
Accessions	CAI75184 CAJ41837 CAL33803 CAS97665 CAT02303 CBY45349 CBY45409 CDL78890 EAW56869 Q8IZI9 AY129149 AAN28264 AY184374 AAN86127 AY336714 AAR24509 AY336717 AAQ01561 BC130314 AAI30315 BC130316 AAI30317 HQ258095 ADR82849 XM_005258765 XP_005258822 XM_011526757 XP_011525059 NM_172139 NP_742151
Function	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
Subcellular Location	Secreted {ECO:0000269|PubMed:12483210}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL28B ELISA Kit (Sandwich ELISA) - LS-F4455 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.64 pg/ml Range 32-2000 pg/ml

Human IL28B ELISA Kit (Sandwich ELISA) - LS-F646 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 32-2000 pg/ml

Human IL28B ELISA Kit (Sandwich ELISA) - LS-F11775 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 15.6 Range 32-2000 pg/ml

Human IL-28B/IFN-lambda 3 DuoSet ELISA - DY5259 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Mouse IL-28A/B (IFN-lambda 2/3) DuoSet ELISA - DY1789B from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

IL-28B ELISA Kit (Human) : 96 Wells (OKAG00147) - OKAG00147 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 32 pg/mL Range 32-2,000 pg/mL

Interleukin 28B (IL-28B), Human, ELISA Kit - CSB-E13296h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.39 pg/ml Range 1.56 pg/ml -100 pg/ml

Interleukin 28B (IL28B), Human, ELISA Kit - SEC028Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 5.6pg/mL Range 15.6-1,000pg/mL

Interleukin-28B, IL28B, Human, ELISA Kit - E2028h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 15.6-1000 pg/mL

Interleukin 28B (IL28B), Human, CLIA Kit - SCC028Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 3.8pg/mL Range 15.6-1,000pg/mL

IL28B (Human) ELISA Kit - KA2216 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

IL28B ELISA Kit - KE00014 from Acris Antibodies Category ELISA Kit Prices $599.00 Sizes 1 kit Range 0.8 pg/ml

Human IL28B ELISA Kit - KE00014 from Proteintech Group Category ELISA Kit Prices $599.00 Sizes 1 Sensitivity 0.8 pg/mL Range 15.6 pg/mL-1000 pg/mL

IL-28B, ELISA Kit - MBS2515870 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 9.375pg/mL Range 15.625-1000pg/mL

IL-28B (Human) OmniKine™ ELISA Kit - OK-0247 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range 32-2000 pg/ml

Human IL-28B ELISA Kit - DEIA8010 from Creative Diagnostics Category ELISA Kit

Interleukin 28B, ELISA Kit - MBS088340 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 28B, ELISA Kit - MBS071467 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 28B, ELISA Kit - MBS086338 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 28B, ELISA Kit - MBS087621 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 28B, ELISA Kit - MBS078919 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 28B, ELISA Kit - MBS100690 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.0 pg/ml. Range 15.6 pg/ml - 500 pg/ml.

Interleukin 28B, ELISA Kit - MBS089705 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 28B, ELISA Kit - MBS094867 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 28B, ELISA Kit - MBS095907 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.0 pg/ml. Range 15.6 pg/ml - 500 pg/ml.

Search more