| Gene Symbol |
IFNL3
|
| Entrez Gene |
282617
|
| Alt Symbol |
IL-28B, IL28B, IL28C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon, lambda 3
|
| Other Description |
IFN-lambda-3|IFN-lambda-4|IL-28C|cytokine Zcyto22|interferon lambda-3|interferon lambda-4|interferon, lambda 4|interleukin 28B (interferon, lambda 3)|interleukin 28C|interleukin-28B|interleukin-28C
|
| Swissprots |
A2BDE1 Q8IWL6 Q7Z4J3 Q6VN56 Q8IZI9
|
| Accessions |
CAI75184 CAJ41837 CAL33803 CAS97665 CAT02303 CBY45349 CBY45409 CDL78890 EAW56869 Q8IZI9 AY129149 AAN28264 AY184374 AAN86127 AY336714 AAR24509 AY336717 AAQ01561 BC130314 AAI30315 BC130316 AAI30317 HQ258095 ADR82849 XM_005258765 XP_005258822 XM_011526757 XP_011525059 NM_172139 NP_742151
|
| Function |
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:12483210}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
|
