IFNL3

Gene Symbol	IFNL3
Entrez Gene	282617
Alt Symbol	IL-28B, IL28B, IL28C
Species	Human
Gene Type	protein-coding
Description	interferon, lambda 3
Other Description	IFN-lambda-3|IFN-lambda-4|IL-28C|cytokine Zcyto22|interferon lambda-3|interferon lambda-4|interferon, lambda 4|interleukin 28B (interferon, lambda 3)|interleukin 28C|interleukin-28B|interleukin-28C
Swissprots	A2BDE1 Q8IWL6 Q7Z4J3 Q6VN56 Q8IZI9
Accessions	CAI75184 CAJ41837 CAL33803 CAS97665 CAT02303 CBY45349 CBY45409 CDL78890 EAW56869 Q8IZI9 AY129149 AAN28264 AY184374 AAN86127 AY336714 AAR24509 AY336717 AAQ01561 BC130314 AAI30315 BC130316 AAI30317 HQ258095 ADR82849 XM_005258765 XP_005258822 XM_011526757 XP_011525059 NM_172139 NP_742151
Function	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
Subcellular Location	Secreted {ECO:0000269|PubMed:12483210}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL28B full length protein - ab201872 from Abcam Category Protein Source Insect cells Species Human

IL28B Antibody Blocking Peptide - LS-E4521 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL28B Antibody Blocking Peptide - LS-E23235 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL28B-Antibody-N-term-Blocking-Peptide - BP16853a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human IL-28B/IFN-lambda 3 - 5259-IL-025 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Arg30-Val200, with the variant of Lys74Arg and a C-terminal 6-His tag

Recombinant Human IL-28B/IFN-lambda 3, CF - 5259-IL-025/CF from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Arg30-Val200, with the variant of Lys74Arg and a C-terminal 6-His tag

Human IL 28B protein - orb84156 from Biorbyt Category Protein Prices $162.00, $323.00, $612.00 Sizes 5 μg, 20 μg, 50 μg Source Human Species Human

Human IL 28B protein - orb168634 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human IL-28B protein - orb180319 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source Human Cells Species Human

Mouse IL 28B protein - orb168635 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Mouse

IFNL3 protein - 80R-4218 from Fitzgerald Category Protein Prices $295.00 Sizes 50 µg Source Insect cells

Interleukin-28B (22-196, His-tag) - AR51900PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Species Human

Interleukin-28B (22-196, His-tag) - AR51900PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Species Human

Interleukin-28B, Human Recombinant - 228-11974-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source HEK. Species Human

Recombinant Human Interleukin-28B - 228-11974-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source HEK. Species Human

Recombinant Human Interleukin-28B - 228-11974-3 from RayBiotech Category Protein Source HEK. Species Human

Interleukin 28B (IL28B), Human - 20-8284 from ARP American Research Products Category Protein Prices $419.00 Sizes 50 µg Source E.coli Species Human

IL-28B Peptide - 7479P from ProSci Category Peptide Species Human

IL28B fusion protein - ag21491 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

IL 28B Human - CYPS-112 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source HEK. Species Human

Recombinant Human IL-28B Protien - BP002450-CA25 from Syd Labs Category Protein Prices $180.00, $378.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human IL-28B Protien - BP002450-CYT-105 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source HEK-derived. Species Human

Recombinant Human IFNL3, His-tagged - IFNL3-8465H from Creative Biomart Category Protein Source Insect Cells Species Human

Recombinant Human IFNL3, His-tagged - IFNL3-405H from Creative Biomart Category Protein Source CHO cells Species Human

Recombinant Human IFNL3, His-tagged - IFNL3-12H from Creative Biomart Category Protein Source Baculovirus Species Human

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