| Gene Symbol | IFNL3 |
|---|---|
| Entrez Gene | 282617 |
| Alt Symbol | IL-28B, IL28B, IL28C |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon, lambda 3 |
| Other Description | IFN-lambda-3|IFN-lambda-4|IL-28C|cytokine Zcyto22|interferon lambda-3|interferon lambda-4|interferon, lambda 4|interleukin 28B (interferon, lambda 3)|interleukin 28C|interleukin-28B|interleukin-28C |
| Swissprots | A2BDE1 Q8IWL6 Q7Z4J3 Q6VN56 Q8IZI9 |
| Accessions | CAI75184 CAJ41837 CAL33803 CAS97665 CAT02303 CBY45349 CBY45409 CDL78890 EAW56869 Q8IZI9 AY129149 AAN28264 AY184374 AAN86127 AY336714 AAR24509 AY336717 AAQ01561 BC130314 AAI30315 BC130316 AAI30317 HQ258095 ADR82849 XM_005258765 XP_005258822 XM_011526757 XP_011525059 NM_172139 NP_742151 |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express |
| Subcellular Location | Secreted {ECO:0000269|PubMed:12483210}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
IL-28B CRISPR/Cas9 KO Plasmid (h) - sc-406651 from Santa Cruz Biotechnology
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IL-28B HDR Plasmid (h) - sc-406651-HDR from Santa Cruz Biotechnology
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IL-28B Double Nickase Plasmid (h) - sc-406651-NIC from Santa Cruz Biotechnology
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IL-28B Double Nickase Plasmid (h2) - sc-406651-NIC-2 from Santa Cruz Biotechnology
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IL-28B CRISPR Activation Plasmid (h) - sc-406651-ACT from Santa Cruz Biotechnology
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IL-28B CRISPR Activation Plasmid (h2) - sc-406651-ACT-2 from Santa Cruz Biotechnology
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IL-28B Lentiviral Activation Particles (h) - sc-406651-LAC from Santa Cruz Biotechnology
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IL-28B Lentiviral Activation Particles (h2) - sc-406651-LAC-2 from Santa Cruz Biotechnology
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IL-28B siRNA (h) - sc-105568 from Santa Cruz Biotechnology
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IL-28B shRNA Plasmid (h) - sc-105568-SH from Santa Cruz Biotechnology
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IL-28B shRNA (h) Lentiviral Particles - sc-105568-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN1269 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1269 from Sigma-Aldrich
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IFNL3 siRNA (Human) - CRJ6846 from Cohesion Biosciences
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IFNL3 - MBS8201167 from MyBioSource
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shRNA set against Human IL28B(NM_172139.2) - SHL173064 from Creative biogene
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Human IFNL3 siRNA - orb277347 from Biorbyt
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IFNL3 shRNA Plasmid (Human) - CHJ6846 from Cohesion Biosciences
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IL28B miRNA 3'UTR clone - MiUTR1H-04915 from Creative biogene
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