Gene Symbol | GFRA2 |
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Entrez Gene | 2675 |
Alt Symbol | GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2 |
Species | Human |
Gene Type | protein-coding |
Description | GDNF family receptor alpha 2 |
Other Description | GDNF family receptor alpha-2|GDNF receptor beta|GDNFR-alpha-2|GDNFR-beta|GFR-alpha 2|NTNR-alpha|PI-linked cell-surface accessory protein|RET ligand 2|TGF-beta-related neurotrophic factor receptor 2|TRN receptor, GPI-anchored|glial cell line derived neurotrophic factor receptor, beta|neurturin receptor alpha |
Swissprots | O15328 Q6GTR9 Q7Z5C2 O15316 E9PD47 Q58J92 O00451 |
Accessions | CAM55948 EAW63742 O00451 AF002700 AAC52036 AK299623 BAG61551 AY326396 AAP88378 AY941828 AAX46325 BC041688 AAH41688 JF432396 ADZ15613 U93703 AAB61922 U97145 AAC51647 XM_005273475 XP_005273532 XM_006716327 XP_006716390 XM_011544484 XP_011542786 XM_011544485 XP_011542787 NM_001165038 NP_001158510 NM_001165039 NP_001158511 NM_001495 NP_001486 |
Function | Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. |
Subcellular Location | Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. |
Tissue Specificity | Isoform 1 is found in both brain and placenta. |
GFRα-2 CRISPR/Cas9 KO Plasmid (h) - sc-404010 from Santa Cruz Biotechnology
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GFRα-2 HDR Plasmid (h) - sc-404010-HDR from Santa Cruz Biotechnology
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GFRα-2 Double Nickase Plasmid (h) - sc-404010-NIC from Santa Cruz Biotechnology
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GFRα-2 Double Nickase Plasmid (h2) - sc-404010-NIC-2 from Santa Cruz Biotechnology
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GFRα-2 CRISPR Activation Plasmid (h) - sc-404010-ACT from Santa Cruz Biotechnology
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GFRα-2 CRISPR Activation Plasmid (h2) - sc-404010-ACT-2 from Santa Cruz Biotechnology
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GFRα-2 Lentiviral Activation Particles (h) - sc-404010-LAC from Santa Cruz Biotechnology
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GFRα-2 Lentiviral Activation Particles (h2) - sc-404010-LAC-2 from Santa Cruz Biotechnology
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GFRα-2 siRNA (h) - sc-35471 from Santa Cruz Biotechnology
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GFRα-2 shRNA Plasmid (h) - sc-35471-SH from Santa Cruz Biotechnology
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GFRα-2 shRNA (h) Lentiviral Particles - sc-35471-V from Santa Cruz Biotechnology
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GFR alpha-2/GDNF R alpha-2 RNAi - H00002675-R02 from Novus Biologicals
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MISSION® esiRNA - EHU118501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9248 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9248 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08711 from Sigma-Aldrich
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GFRA2 siRNA (Human) - CRH1784 from Cohesion Biosciences
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GFRA2 - MBS8212942 from MyBioSource
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shRNA set against Human GFRA2 (NM_001495.4) - SHH300686 from Creative biogene
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shRNA set against Human GFRA2(NM_001495.4) - SHH082667 from Creative biogene
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Human GFRA2 siRNA - orb262286 from Biorbyt
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GFRA2 shRNA Plasmid (Human) - CHH1784 from Cohesion Biosciences
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GFRA2 miRNA 3'UTR clone - MiUTR1H-04016 from Creative biogene
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GFRA2 miRNA 3'UTR clone - MiUTR3H-04528 from Creative biogene
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GFRA2 miRNA 3'UTR clone - MiUTR3H-04529 from Creative biogene
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