| Gene Symbol |
ATF7
|
| Entrez Gene |
11016
|
| Alt Symbol |
ATFA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
activating transcription factor 7
|
| Other Description |
cyclic AMP-dependent transcription factor ATF-7|transcription factor ATF-A
|
| Swissprots |
Q8IVR8 P17544 B4DQL4 A5D6Y4 Q9UD83 B2RMP1 Q13814
|
| Accessions |
EAW96723 EAW96724 P17544 AA679547 AK298853 BAG60976 AK302907 BAG64077 AK310355 AK313507 BAG36287 BC032433 BC042363 AAH42363 BC136302 AAI36303 BC140006 AAI40007 BP279417 BP312300 BQ184780 DB047160 DB490927 X52943 CAA37118 X57197 CAA40483 XM_005268587 XP_005268644 XM_011537776 XP_011536078 XM_011537777 XP_011536079 XM_011537778 XP_011536080 NM_001130059 NM_001130060 NP_001123532 NM_001206682 NP_001193611 NM_001206683 NP_001193612 NM_006856 NP_006847 NR_073163
|
| Function |
Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:17264123}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17264123}. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.
|
| Tissue Specificity |
Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta. {ECO:0000269|PubMed:8288576}.
|