Gene Symbol | ATF7 |
---|---|
Entrez Gene | 11016 |
Alt Symbol | ATFA |
Species | Human |
Gene Type | protein-coding |
Description | activating transcription factor 7 |
Other Description | cyclic AMP-dependent transcription factor ATF-7|transcription factor ATF-A |
Swissprots | Q8IVR8 P17544 B4DQL4 A5D6Y4 Q9UD83 B2RMP1 Q13814 |
Accessions | EAW96723 EAW96724 P17544 AA679547 AK298853 BAG60976 AK302907 BAG64077 AK310355 AK313507 BAG36287 BC032433 BC042363 AAH42363 BC136302 AAI36303 BC140006 AAI40007 BP279417 BP312300 BQ184780 DB047160 DB490927 X52943 CAA37118 X57197 CAA40483 XM_005268587 XP_005268644 XM_011537776 XP_011536078 XM_011537777 XP_011536079 XM_011537778 XP_011536080 NM_001130059 NM_001130060 NP_001123532 NM_001206682 NP_001193611 NM_001206683 NP_001193612 NM_006856 NP_006847 NR_073163 |
Function | Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:17264123}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17264123}. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery. |
Tissue Specificity | Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta. {ECO:0000269|PubMed:8288576}. |
ATF-7 CRISPR/Cas9 KO Plasmid (h) - sc-409230 from Santa Cruz Biotechnology
|
||||||||
ATF-7 HDR Plasmid (h) - sc-409230-HDR from Santa Cruz Biotechnology
|
||||||||
ATF-7 Double Nickase Plasmid (h) - sc-409230-NIC from Santa Cruz Biotechnology
|
||||||||
ATF-7 Double Nickase Plasmid (h2) - sc-409230-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ATF-7 CRISPR Activation Plasmid (h) - sc-409230-ACT from Santa Cruz Biotechnology
|
||||||||
ATF-7 CRISPR Activation Plasmid (h2) - sc-409230-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ATF-7 Lentiviral Activation Particles (h) - sc-409230-LAC from Santa Cruz Biotechnology
|
||||||||
ATF-7 Lentiviral Activation Particles (h2) - sc-409230-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ATF-7 siRNA (h) - sc-29759 from Santa Cruz Biotechnology
|
||||||||
ATF-7 shRNA Plasmid (h) - sc-29759-SH from Santa Cruz Biotechnology
|
||||||||
ATF-7 shRNA (h) Lentiviral Particles - sc-29759-V from Santa Cruz Biotechnology
|
||||||||
ATF7 RNAi - H00011016-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU095041 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN3639 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3639 from Sigma-Aldrich
|
||||||||
ATF7 siRNA (Human) - CRH7525 from Cohesion Biosciences
|
||||||||
ATF7 - MBS8210886 from MyBioSource
|
||||||||
shRNA set against Human Atf7 (NM_006856.2) - SHH241978 from Creative biogene
|
||||||||
Human ATF7 siRNA - orb268027 from Biorbyt
|
||||||||
ATF7 shRNA Plasmid (Human) - CHH7525 from Cohesion Biosciences
|