ATG3

Gene Symbol	ATG3
Entrez Gene	64422
Alt Symbol	APG3, APG3-LIKE, APG3L, PC3-96
Species	Human
Gene Type	protein-coding
Description	autophagy related 3
Other Description	2610016C12Rik|ATG3 autophagy related 3 homolog|autophagy-related protein 3|hApg3|ubiquitin-like-conjugating enzyme ATG3
Swissprots	Q6PKC5 Q9H6L9 Q9NT62
Accessions	EAW79668 EAW79669 EAW79670 EAW79671 Q9NT62 AA448974 AB079384 BAB90843 AF202092 AAG35611 AK025778 BAB15237 AK123511 AK307432 AK308919 AL137515 CAB70781 AW408464 BC002830 AAH02830 BC024221 AAH24221 BC043267 DC311625 DQ893424 ABM84350 DQ896774 ABM87773 XM_011513074 XP_011511376 NM_001278712 NP_001265641 NM_022488 NP_071933
Function	E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriola
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11825910}.
Tissue Specificity	Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta. {ECO:0000269|PubMed:11825910}.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Apg3 full length protein - ab188738 from Abcam Category Protein Prices $276.00 Sizes 50 µg Source E. coli Species Human

Human Apg3 full length protein - ab131936 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Apg3 full length protein - ab181942 from Abcam Category Protein Prices $301.00 Sizes 100 µg Source E. coli Species Human

Human Apg3 peptide - ab66285 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Apg3 peptide - ab66286 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Apg3 protein fragment - ab152071 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source E. coli Species Human

Human Apg3 protein fragment - ab163838 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

ATG3 Antibody Blocking Peptide - LS-E5552 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATG3 Antibody Blocking Peptide - LS-E5553 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATG3 Antibody Blocking Peptide - LS-E19519 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATG3 Antibody Blocking Peptide - LS-E30940 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ATG3 Antibody Blocking Peptide - LS-E7476 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATG3 Antibody Blocking Peptide - LS-E21604 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATG3/APG3 Recombinant Protein - H00064422-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ATG3/APG3 Partial Recombinant Protein - H00064422-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ATG3/APG3 Peptide - NBP1-77168PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

ATG3-Antibody-C-term-Blocking-peptide - BP1807b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG3-Antibody-N-term-Blocking-peptide - BP1807a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APG3cleaved-Antibody-Blocking-peptide - BP3740a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG3 Peptide - GTX85005-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Recombinant Human His6-ATG3, CF - E2-670-050 from R&D Systems Category Protein Source E. coli-derived, Contains a C-terminal 6-His tag

Recombinant Human His6-ATG3, CF - E2-670-100 from R&D Systems Category Protein Source E. coli-derived, Contains a C-terminal 6-His tag

Human ATG3 protein - orb246299 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human ATG3 protein - orb49722 from Biorbyt Category Protein Species Human

ATG3 Blocking Peptide - 33R-5556 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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