ATG3

Gene Symbol ATG3
Entrez Gene 64422
Alt Symbol APG3, APG3-LIKE, APG3L, PC3-96
Species Human
Gene Type protein-coding
Description autophagy related 3
Other Description 2610016C12Rik|ATG3 autophagy related 3 homolog|autophagy-related protein 3|hApg3|ubiquitin-like-conjugating enzyme ATG3
Swissprots Q6PKC5 Q9H6L9 Q9NT62
Accessions EAW79668 EAW79669 EAW79670 EAW79671 Q9NT62 AA448974 AB079384 BAB90843 AF202092 AAG35611 AK025778 BAB15237 AK123511 AK307432 AK308919 AL137515 CAB70781 AW408464 BC002830 AAH02830 BC024221 AAH24221 BC043267 DC311625 DQ893424 ABM84350 DQ896774 ABM87773 XM_011513074 XP_011511376 NM_001278712 NP_001265641 NM_022488 NP_071933
Function E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriola
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11825910}.
Tissue Specificity Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta. {ECO:0000269|PubMed:11825910}.
Top Pathways Regulation of autophagy

Atg3 CRISPR/Cas9 KO Plasmid (h) - sc-403308 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg3 HDR Plasmid (h) - sc-403308-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg3 Double Nickase Plasmid (h) - sc-403308-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg3 Double Nickase Plasmid (h2) - sc-403308-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg3 CRISPR Activation Plasmid (h) - sc-403308-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg3 CRISPR Activation Plasmid (h2) - sc-403308-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg3 Lentiviral Activation Particles (h) - sc-403308-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg3 Lentiviral Activation Particles (h2) - sc-403308-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg3 siRNA (h) - sc-72582 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Atg3 shRNA Plasmid (h) - sc-72582-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Atg3 shRNA (h) Lentiviral Particles - sc-72582-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ATG3/APG3 RNAi - H00064422-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU015141 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN3650 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3650 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00966 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00966

ATG3 siRNA (Human) - CRJ2018 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ATG3 - MBS8200371 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ATG3 (NM_022488.3) - SHH242106 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ATG3(NM_022488.3) - SHG079867 from Creative biogene

Category siRNA
Species Reactivities Human

ATG3 shRNA Plasmid (Human) - CHJ2018 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ATG3 miRNA 3'UTR clone - MiUTR1H-00661 from Creative biogene

Species Reactivities Human
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