SLC7A7

Gene Symbol SLC7A7
Entrez Gene 9056
Alt Symbol LAT3, LPI, MOP-2, Y+LAT1, y+LAT-1
Species Human
Gene Type protein-coding
Description solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
Other Description Y+L amino acid transporter 1|monocyte amino acid permease 2|solute carrier family 7 (cationic amino acid transporter, y+ system), member 7|y(+)L-type amino acid transporter 1
Swissprots Q86U07 Q9P2V5 B2RAU0 Q53XC1 O95984 D3DS26 Q9UM01
Accessions BAA95120 EAW66245 EAW66246 EAW66247 EAW66248 Q9UM01 AB011263 BAB11849 AB020532 BAA87623 AB209591 BAD92828 AF092032 AAC83706 AJ130718 CAA10198 AK025377 AK301219 BAG62792 AK309128 AK314351 BAG36987 AL365450 AL365451 AL365452 BC003062 AAH03062 BC010107 AAH10107 BX161519 CAD61952 BX248291 CAD62619 DA044956 DA638578 DA950997 DA991442 DB170842 DQ891835 ABM82761 DQ895021 ABM85947 Y18474 CAB40136 XM_006720302 XP_006720365 XM_011537298 XP_011535600 XM_011537299 XP_011535601 NM_001126105 NP_001119577 NM_001126106 NP_001119578 NR_040448 NM_003982
Function Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes. {ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.
Subcellular Location Basolateral cell membrane {ECO:0000269|PubMed:15756301}; Multi-pass membrane protein {ECO:0000269|PubMed:15756301}.
Tissue Specificity Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, retinal pigment epithelial cells, and various carcinoma cell lines, with highest expression in a colon-carcinoma cell line. {ECO:0000269|PubMed:10080183, ECO:0000269|PubMed:11078698, ECO:0000269|PubMed:11742806, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:9829974}.
Top Pathways Protein digestion and absorption

YLAT1 CRISPR/Cas9 KO Plasmid (h) - sc-404403 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

YLAT1 HDR Plasmid (h) - sc-404403-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

YLAT1 Double Nickase Plasmid (h) - sc-404403-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

YLAT1 Double Nickase Plasmid (h2) - sc-404403-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

YLAT1 CRISPR Activation Plasmid (h) - sc-404403-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

YLAT1 CRISPR Activation Plasmid (h2) - sc-404403-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

YLAT1 Lentiviral Activation Particles (h) - sc-404403-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

YLAT1 Lentiviral Activation Particles (h2) - sc-404403-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Y+LAT1 siRNA (h) - sc-45427 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Y+LAT1 shRNA Plasmid (h) - sc-45427-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Y+LAT1 shRNA (h) Lentiviral Particles - sc-45427-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SLC7A7 RNAi - H00009056-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU021471 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19693 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19693 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03132 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03132

SLC7A7 siRNA (Human) - CRH5977 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC7A7 - MBS8205473 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Y+LAT1 CRISPR/Cas9 KO Plasmid (h2) - sc-404403-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Y+LAT1 HDR Plasmid (h2) - sc-404403-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Human SLC7A7 siRNA - orb266479 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC7A7 shRNA Plasmid (Human) - CHH5977 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC7A7 miRNA 3'UTR clone - MiUTR3H-06097 from Creative biogene

Species Reactivities Human

SLC7A7 miRNA 3'UTR clone - MiUTR3H-06098 from Creative biogene

Species Reactivities Human
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