SLC7A7

Gene Symbol	SLC7A7
Entrez Gene	9056
Alt Symbol	LAT3, LPI, MOP-2, Y+LAT1, y+LAT-1
Species	Human
Gene Type	protein-coding
Description	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
Other Description	Y+L amino acid transporter 1|monocyte amino acid permease 2|solute carrier family 7 (cationic amino acid transporter, y+ system), member 7|y(+)L-type amino acid transporter 1
Swissprots	Q86U07 Q9P2V5 B2RAU0 Q53XC1 O95984 D3DS26 Q9UM01
Accessions	BAA95120 EAW66245 EAW66246 EAW66247 EAW66248 Q9UM01 AB011263 BAB11849 AB020532 BAA87623 AB209591 BAD92828 AF092032 AAC83706 AJ130718 CAA10198 AK025377 AK301219 BAG62792 AK309128 AK314351 BAG36987 AL365450 AL365451 AL365452 BC003062 AAH03062 BC010107 AAH10107 BX161519 CAD61952 BX248291 CAD62619 DA044956 DA638578 DA950997 DA991442 DB170842 DQ891835 ABM82761 DQ895021 ABM85947 Y18474 CAB40136 XM_006720302 XP_006720365 XM_011537298 XP_011535600 XM_011537299 XP_011535601 NM_001126105 NP_001119577 NM_001126106 NP_001119578 NR_040448 NM_003982
Function	Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes. {ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.
Subcellular Location	Basolateral cell membrane {ECO:0000269|PubMed:15756301}; Multi-pass membrane protein {ECO:0000269|PubMed:15756301}.
Tissue Specificity	Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, retinal pigment epithelial cells, and various carcinoma cell lines, with highest expression in a colon-carcinoma cell line. {ECO:0000269|PubMed:10080183, ECO:0000269|PubMed:11078698, ECO:0000269|PubMed:11742806, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:9829974}.
Top Pathways	Protein digestion and absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Y+LAT1 (C-16) - sc-34551 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Y+LAT1 (H-55) - sc-67129 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Y+LAT1 (L-13) - sc-34552 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Y+LAT1 (N-17) - sc-34553 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Y+LAT1 (V-13) - sc-34554 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SLC7A7 antibody - ab104994 from Abcam Host Rabbit Clonality Polyclonal

Anti-SLC7A7 antibody - ab69872 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-SLC7A7 antibody - ab106610 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SLC7A7 Antibody (aa179-228) - LS-C110831 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-SLC7A7 Antibody - LS-C179214 from LifeSpan Bioscience Prices $365.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

SLC7A7 Antibody - NBP1-59856 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

SLC7A7 Antibody - NBP1-82826 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC7A7 Antibody - H00009056-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

SLC7A7 Antibody - NBP1-70387 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC7A7 Antibody (3B10) - H00009056-M04 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3B10

Anti-SLC7A7 antibody produced in rabbit - HPA036227 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SLC7A7 antibody produced in mouse - SAB1406773 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Monoclonal Anti-SLC7A7, (C-terminal) antibody produced in mouse - SAB1402443 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3B10

Anti-SLC7A7 antibody produced in rabbit - SAB2105535 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC7A7 antibody - middle region (ARP43863_P050) - ARP43863_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC7A7 antibody - 70R-6771 from Fitzgerald Prices $345.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

SLC7A7 antibody - H00009056-B01P from Acris Antibodies Prices $360.00 Sizes 50 µg Host Mouse Clonality Polyclonal

SLC7A7 antibody - H00009056-M04 from Acris Antibodies Prices $360.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3B10

SLC7A7 Antibody - GWB-MP631A from Genway Biotech Prices $368.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

SLC7A7, Monoclonal Antibody - MBS6006561 from MyBioSource Prices $580.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3B10

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