ASZ1
| Gene Symbol | ASZ1 |
|---|---|
| Entrez Gene | 136991 |
| Alt Symbol | ALP1, ANKL1, C7orf7, CT1.19, GASZ, Orf3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ankyrin repeat, SAM and basic leucine zipper domain containing 1 |
| Other Description | ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1|ankyrin-like 1|ankyrin-like protein 1|germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein |
| Swissprots | B7ZM20 Q8WWH4 A4D0V0 A0AV27 |
| Accessions | CBH19198 CBH30664 EAL24354 EAW83526 EAW83527 EAW83528 Q8WWH4 AF461259 AAL68815 AK093445 BAC04167 BC028695 BC034963 AAH34963 BC068488 BC098399 BC126186 AAI26187 BC126188 AAI26189 BC144207 BC144212 AAI44213 DB457846 HQ258436 ADR83190 XM_011515802 XP_011514104 NR_023315 NM_001301821 NP_001288750 NM_001301822 NP_001288751 NM_130768 NP_570124 |
| Function | Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi- bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed exclusively in the testis and ovary and at higher levels in the adult testis compared with the adult ovary. {ECO:0000269|PubMed:12040005}. |
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![Western Blot: ASZ1 Antibody [NBP1-57071] - THP-1 tissue lysate at a concentration of 1ug/ml.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_3/7568_ASZ1%2520Antibody-Western%2520Blot-NBP1-57071-img0001.jpg)
![Immunocytochemistry/Immunofluorescence: ASZ1 Antibody [NBP1-89130] - Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_8/25017_ASZ1%2520Antibody-Immunocytochemistry-Immunofluorescence-NBP1-89130-img0006.jpg)
![Western Blot: ASZ1 Antibody [H00136991-A01] - ASZ1 polyclonal antibody (A01), Lot # 061130JCS1 Western Blot analysis of ASZ1 expression in HeLa ( Cat # L013V1 ).](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_5/5825_ASZ1-Antibody-Western-Blot-H00136991-A01-img0001.jpg)
![Western Blot: ASZ1 Antibody [H00136991-B01P] - Analysis of ASZ1 expression in transfected 293T cell line by ASZ1 polyclonal antibody. Lane 1: ASZ1 transfected lysate(43.23 KDa). Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_10/18609_ASZ1%2520Antibody-Western%2520Blot-H00136991-B01P-img0003.jpg)
![Western Blot: ASZ1 Antibody (3C9) [H00136991-M01] - Analysis of ASZ1 expression in transfected 293T cell line by ASZ1 monoclonal antibody (M01), clone 3C9.Lane 1: ASZ1 transfected lysate (Predicted MW: 44 KDa).Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_10/10243_ASZ1%2520Antibody%2520(3C9)-Western%2520Blot-H00136991-M01-img0002.jpg)
