MCRS1

Gene Symbol	MCRS1
Entrez Gene	10445
Alt Symbol	ICP22BP, INO80Q, MCRS2, MSP58, P78
Species	Human
Gene Type	protein-coding
Description	microspherule protein 1
Other Description	58 kDa microspherule protein\|INO80 complex subunit J\|INO80 complex subunit Q\|cell cycle-regulated factor (78 kDa)\|cell cycle-regulated factor p78
Swissprots	O14742 O75497 Q6VN53 Q96EZ8 Q7Z372
Accessions	CCQ43031 EAW58075 EAW58076 EAW58077 EAW58078 EAW58079 EAW58080 Q96EZ8 AF015308 AAC52086 AF068007 AAC68599 AK308581 AY336730 AAQ84517 BC011794 AAH11794 BX538079 CAD98003 DQ892887 ABM83813 EU176727 ABW03528 HY078747 R66413 XM_005268572 XP_005268629 XM_011537760 XP_011536062 NM_001012300 NP_001012300 NM_001278341 NP_001265270 NM_006337 NP_006328
Function	Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. {ECO:0000269\|PubMed:11948183, ECO:0000269\|PubMed:15044100, ECO:0000269\|PubMed:20018852}.
Subcellular Location	Nucleus. Nucleus, nucleolus. Note=In microspherules in the nucleolus.
Tissue Specificity	Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.
Top Pathways	Herpes simplex infection

MSP58 (B-5) - sc-376569 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

MSP58 (B-5): sc-376569. Western blot analysis of MSP58 expression in non-transfected (A) and human MSP58 transfected (B) CMV whole cell lysates.

MSP58 (H-300) - sc-135288 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

MSP58 (K-20) - sc-79985 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

MSP58 (K-20): sc-79985. Western blot analysis of MSP58 expression in HeLa (A), Jurkat (B) and F9 (C) whole cell lysates.

Anti-MCRS1 antibody - ab67760 from Abcam

Host	Rabbit
Clonality	Polyclonal

Anti-MCRS1 antibody - ab130698 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MCRS1 antibody (ab130698) at 1/100 dilution + HepG2 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-MCRS1 antibody - ab67393 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-MCRS1 antibody (ab67393) at 1/500 dilutionLane 1 : MCRS1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-MCRS1 antibody [EPR5855] - ab124704 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR5855

All lanes : Anti-MCRS1 antibody [EPR5855] (ab124704) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : HCT 116 cell lysateLane 3 : Jurkat cell lysateLane 4 : LnCaP cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-MCRS1 / MSP58 Antibody (N-Terminus) - LS-C144806 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MCRS1 / MSP58 Antibody (aa35-63, Biotin) - LS-C262865 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MCRS1 / MSP58 Antibody (aa35-63, FITC) - LS-C262866 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MCRS1 / MSP58 Antibody (aa35-63, APC) - LS-C262864 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MCRS1 / MSP58 Antibody (aa35-63, AP) - LS-C262862 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MCRS1 / MSP58 Antibody (aa35-63, Azide-free, HRP) - LS-C262867 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MCRS1 / MSP58 Antibody (aa35-63, PE) - LS-C262868 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MCRS1 / MSP58 Antibody - LS-C308926 from LifeSpan Bioscience

Prices	$455.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-MCRS1 / MSP58 Antibody - LS-C310964 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MCRS1 / MSP58 Antibody (Internal, clone EPR5855) - LS-C138757 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR5855

Western blot analysis on (A) HeLa, (B) HCT-116, (C) Jurkat, (D) LnCaP cell lysates using anti-MCRS1 antibody.

Anti-MCRS1 / MSP58 Antibody (aa35-63) - LS-C164102 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

MCRS1 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The MCRS1 antibody detected the MCRS1 protein (arrow).

Anti-MCRS1 / MSP58 Antibody (aa34-63) - LS-C322920 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

MCRS1 Antibody - H00010445-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

MCRS1 Antibody - NBP1-81615 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: MCRS1 Antibody [NBP1-81615] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

MCRS1 Antibody - H00010445-D01 from Novus Biologicals

Prices	$399.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ANTI-MCRS1(N-TERMINAL) antibody produced in rabbit - SAB1306826 from Sigma-Aldrich

Prices	$326.00
Sizes	40 tst
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-MCRS1 (N-term): <B>Cat. No. SAB1306826</B>: MCRS1 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35 μg/lane).

Anti-MCRS1 antibody produced in mouse - SAB1400385 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Polyclonal Anti-MCRS1, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1400385</B>: Antibody concentration: 3.0 μg/mL using human human spleen tissue.

MCRS1-Antibody-N-term - AP16872a from Abgent, a WuXi AppTec company

Prices	$99.00, $295.00
Sizes	80 µl, 400 µl
Host	Rabbit
Clonality	Polyclonal

MCRS1 Antibody (N-term) (Cat. #AP16872a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MCRS1 antibody detected the MCRS1 protein (arrow).

Search more