| Gene Symbol |
PELI3
|
| Entrez Gene |
246330
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pellino E3 ubiquitin protein ligase family member 3
|
| Other Description |
E3 ubiquitin-protein ligase pellino homolog 3|pellino homolog 3|protein pellino homolog 3
|
| Swissprots |
Q8TED5 Q8N9Q6 Q8TAW7 Q8N3E1 Q8N2H9
|
| Accessions |
CAF86908 EAW74532 EAW74533 EAW74534 EAW74535 EAW74536 Q8N2H9 AF487456 AAO49465 AF487457 AAO49466 AK074201 BAB85015 AK075253 BAC11499 AK094060 BAC04275 AL834395 CAD39057 BC021256 AAH21256 BC025723 AAH25723 BC127759 AAI27760 BX341733 DA203229 XM_011544884 XP_011543186 NM_001098510 NP_001091980 NM_001243135 NP_001230064 NM_001243136 NP_001230065 NM_145065 NP_659502
|
| Function |
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. {ECO:0000269|PubMed:12874243, ECO:0000269|PubMed:17675297}.
|
| Tissue Specificity |
Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung. {ECO:0000269|PubMed:12874243}.
|