Gene Symbol | PELI3 |
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Entrez Gene | 246330 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | pellino E3 ubiquitin protein ligase family member 3 |
Other Description | E3 ubiquitin-protein ligase pellino homolog 3|pellino homolog 3|protein pellino homolog 3 |
Swissprots | Q8TED5 Q8N9Q6 Q8TAW7 Q8N3E1 Q8N2H9 |
Accessions | CAF86908 EAW74532 EAW74533 EAW74534 EAW74535 EAW74536 Q8N2H9 AF487456 AAO49465 AF487457 AAO49466 AK074201 BAB85015 AK075253 BAC11499 AK094060 BAC04275 AL834395 CAD39057 BC021256 AAH21256 BC025723 AAH25723 BC127759 AAI27760 BX341733 DA203229 XM_011544884 XP_011543186 NM_001098510 NP_001091980 NM_001243135 NP_001230064 NM_001243136 NP_001230065 NM_145065 NP_659502 |
Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. {ECO:0000269|PubMed:12874243, ECO:0000269|PubMed:17675297}. |
Tissue Specificity | Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung. {ECO:0000269|PubMed:12874243}. |
Pellino 3 CRISPR/Cas9 KO Plasmid (h) - sc-405232 from Santa Cruz Biotechnology
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Pellino 3 HDR Plasmid (h) - sc-405232-HDR from Santa Cruz Biotechnology
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Pellino 3 Double Nickase Plasmid (h) - sc-405232-NIC from Santa Cruz Biotechnology
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Pellino 3 Double Nickase Plasmid (h2) - sc-405232-NIC-2 from Santa Cruz Biotechnology
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Pellino 3 CRISPR Activation Plasmid (h) - sc-405232-ACT from Santa Cruz Biotechnology
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Pellino 3 CRISPR Activation Plasmid (h2) - sc-405232-ACT-2 from Santa Cruz Biotechnology
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Pellino 3 Lentiviral Activation Particles (h) - sc-405232-LAC from Santa Cruz Biotechnology
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Pellino 3 Lentiviral Activation Particles (h2) - sc-405232-LAC-2 from Santa Cruz Biotechnology
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Pellino 3 siRNA (h) - sc-44403 from Santa Cruz Biotechnology
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Pellino 3 shRNA Plasmid (h) - sc-44403-SH from Santa Cruz Biotechnology
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Pellino 3 shRNA (h) Lentiviral Particles - sc-44403-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN16616 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16616 from Sigma-Aldrich
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PELI3 siRNA (Human) - CRJ6623 from Cohesion Biosciences
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shRNA set against Human PELI3 (NM_145065.2) - SHH373456 from Creative biogene
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Human PELI3 siRNA - orb277124 from Biorbyt
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PELI3 shRNA Plasmid (Human) - CHJ6623 from Cohesion Biosciences
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PELI3 miRNA 3'UTR clone - MiUTR1H-07779 from Creative biogene
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PELI3 miRNA 3'UTR clone - MiUTR3H-10824 from Creative biogene
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